Other names:Ala-Glu-Asp-Pro peptide
Cortagen is a directed synthesis of short peptides following amino acid analysis of Cortexin by Vladimir Khavinson. It has powerful biological regulatory functions with effects on both brain and heart tissues. Cortagen is widely used clinically and experimentally because of its effects on memory, attention, and cortical processes.
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 L. N. Turchaninova, L. I. Kolosova, V. V. Malinin, A. B. Moiseeva, A. D. Nozdrachev, and V. K. Khavinson, “Effect of tetrapeptide cortagen on regeneration of sciatic nerve,” Bull. Exp. Biol. Med., vol. 130, no. 12, pp. 1172–1174, Dec. 2000. [PubMed]
 V. K. Khavinson, “Peptides and Ageing,” Neuro Endocrinol. Lett., vol. 23 Suppl 3, pp. 11–144, 2002. [PubMed].
 S. V. Anisimov, V. K. Khavinson, and V. N. Anisimov, “Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray,” Neuro Endocrinol. Lett., vol. 25, no. 1–2, pp. 87–93, Apr. 2004.. [PubMed]
 V. K. Khavinson, T. A. Lezhava, and V. V. Malinin, “Effects of short peptides on lymphocyte chromatin in senile subjects,”Bull. Exp. Biol. Med., vol. 137, no. 1, pp. 78–81, Jan. 2004, doi: 10.1023/b:bebm.0000024393.40560.05 . [PubMed]
 T. Lezhava, J. Monaselidze, T. Kadotani, N. Dvalishvili, and T. Buadze, “Anti-aging peptide bioregulators induce reactivation of chromatin,” Georgian Med. News, no. 133, pp. 111–115, Apr. 2006.. [PubMed]
 L. S. Kozina, “Effects of bioactive tetrapeptides on free-radical processes,” Bull. Exp. Biol. Med., vol. 143, no. 6, pp. 744–746, Jun. 2007, doi: 10.1007/s10517-007-0230-8. [PubMed]
 T. B. Kazakova et al., “In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes,” Bull. Exp. Biol. Med., vol. 133, no. 6, pp. 614–616, Jun. 2002, doi: 10.1023/a:1020210615148. [PubMed]
 S. Korsching “The neurotrophic factor concept: a reexamination” [The Journal of Neuroscience]
 D.V. Kurkin et al., “Neuroprotective action of Cortexin, Cerebrolysin and Actovegin in acute or chronic brain ischemia in rats” [PubMed]
 Shabanov, Vislobokov “Neuronoprotective action of cortexin and cortagen” [Reviews on Clinical Pharmacology and Drug Therapy]
Scientific Journal paper Author:
Director of the Saint Petersburg Institute of Bioregulation and Gerontology
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.