Cortagen
Other names:Ala-Glu-Asp-Pro peptide
Cortagen is a directed synthesis of short peptides following amino acid analysis of Cortexin by Vladimir Khavinson. It has powerful biological regulatory functions with effects on both brain and heart tissues. Cortagen is widely used clinically and experimentally because of its effects on memory, attention, and cortical processes.
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Properties
Description
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Properties
Amino Acid Sequence: | Ala-Glu-Asp-Pro (AEDP) |
Molecular Formula: | C17H27N5O8 |
Molecular Weight: | 430.17 g/mol |
PubChem CID: | 18439621 |
Synonyms: | SCHEMBL5491754 |
Description
Cortagen Structure
Authoritative source：PepDraw
What is Cortagen?
Cortagen is a derivation of Cortexin with great bioregulatory function and It has gene expression patterns that alter tissue-specific patterns. Cortagen has main function on central nervous system and secondary role in the heart and immune system.
Studies have shown that Cortagen stimulates interleukin-2 expression and helps regulate immune function primarily by reducing autoimmune responses. In animal studies, it has obvious therapeutic effect on vascular and cerebrovascular nerve regeneration after posttraumatic.[2][3]
Cortagen is also thought to be an aging protective peptide that may help restore DNA to a more youthful state, reduce aging, and affect gene expression that is normally silenced by age.
What are the benefits of Cortagen?
Cortagen (Ala-Glu-Asp-Pro) is a synthetic derivative of Cortexin. Cortexin is a well-known peptide extract used for its positive effects on memory, concentration and cerebral cortical processes.
Cortagen affects the development and maintenance of brain well-being. It has a neuroprotective effect, stimulates the regeneration process of neurons and promotes their differentiation. At the same time, it has obvious therapeutic effect on post-traumatic blood vessel and cerebrovascular nerve regeneration. It also prevents the excessive activation of lipid peroxidation and reduces the antioxidant activity of brain tissue.[4][5]
Here are some of the potential benefits and uses of Cortagen based on research and preclinical studies:
Cortagen for neuroprotective and Regenerative:
Cortagen may have neuroprotective properties, helping to protect neurons from damage, and support regenerative processes in neurons, potentially aiding in restoring brain function.
Cortagen for Anti-Inflammatory and Antioxidant :
Cortagen might stabilize the inflammatory response in the central nervous system, promoting a balance between pro- and anti-inflammatory pathways. It may also reduce oxidative stress and lipid peroxidation in brain tissues, thereby exerting antioxidant effects.[6][7]
Cortagen for Brain Injury and Nerve Regeneration:
Animal studies suggest that Cortagen could reduce the long-term consequences of ischemic brain injury and promote the restoration of nerve function following nerve transection or injury.https://www.polypeptide.ltd/
Cortagen for Geroprotective and Anti-Aging :
Cortagen has been mentioned as a geroprotective peptide, potentially helping to restore DNA to a more youthful state, reducing senescence, and influencing gene expression often silenced by age.[8]
What are the side effects of Cortagen?
As a peptide, Cortagan has fewer side effects than other similar drugs, and the peptide has almost no side effects at very low doses. Therefore, when using peptide therapy, you should consult with your doctor and grasp the dosage.
Different doses of Cortagen can produce different side effects.
1)Acute use of Cortagen may produce effects similar to anxiolytics.
2)Acute and subchronic administration can result in motor stimulation without any adverse effects on the mood and affective profile of the patient.
Dosing protocols
Cortagen has different doses for different effects, so it is recommended to consult with your doctor carefully before use.[10]
Cortagen and Pinealon
Cortagen and Pinealon are synthetic bioregulatory peptides that affect the brain and central nervous system. It also has the potential to anti-aging and treat Alzheimer’s disease. But they are distinct in their mechanisms and applications.
The anti-aging effect of Cortagen is mainly reflected in its ability to reverse the process of DNA transition from euchromatin to heterochromatin, so that cells can return to a younger state. In addition to this, Cortagen can also affect the aging process by enhancing the body’s natural antioxidant mechanisms.
The anti-aging effects of Pinealon act mainly on the central nervous system, leading to a slowing down of the aging process by manifesting anabolic properties in the brain. Secondly, Pinealon can also regulate the expression of irisin, which is thought to contribute to telomere elongation. By prolonging the lifespan of irisin, Pinealon enhances telomere protection, thereby counteracting the effects of aging and oxidative stress.[1]
Therefore, although both Cortagen and Pinealon have anti-aging effects, their mechanisms of action and methods of use are different. If you are considering buying Cortagen and Pinealon for peptide therapy, be sure to consult with a professional healthcare professional to determine the best course of treatment based on your medical condition and medical history.
Cortagan and Cortexin
Cortagen is a synthetic derivative of Cortexin. They have almost similar functions and effects. If you are using Cortexin or you are interested in Cortexin, you can also try Cortagen. Polypeptide.ltd is a professional peptide manufacturer, where you can buy any peptide you are interested in.[9]
Manufacturers/Factory
Cortagen is a biological regulatory peptide that acts mainly in the brain and central nervous system. It has been investigated as a potential treatment after ischemic brain injury, and it and similar compounds have shown beneficial long-term effects. If you are interested in buying Cortagen, Polypeptide.ltd is the best place.
Being a nootropic peptide, Cortagen plays a important role in the neuroprotective and regenerative, anti-Inflammatory and antioxidant, brain injury and nerve regeneration and geroprotective and anti-aging.
As the best Cortagen peptide manufacturer, Polypeptide.ltd is not only supply the peptide Cortagen in powder form but provide the customized standard easy use vial form.
You can buy the best price Cortagen and best quality peptide from this professional peptide manufacturer.
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Where to buy?
Welcome to Polypeptide.ltd! You find the best place to buy Cortagen!
Polypeptide is a peptide manufacturer in China where you can buy Cortagen in most competitive price, from small to bulk market. Click and make a contact, you will get all the details. Before buy Cortagen, you may curious:
What Are The Advantages If Buy Cortagen From Polypeptide.ltd?
- Competitive Factory Price-Factory direct sales, No middlemen make a difference.
- Customization Service-Product specifications can be customized to create your own peptide brand.
- Quality Guarantee-Professional lab reports along with shipment.
- Fast Shipping-Professional logistics customization solutions, on-time delivery.
- Easy Payment-Payment methods that are diverse.
- 365/24/7 Service-High quality pre-sales and after-sales service, followed by product and order details consultation.
How To Get The Quick Price Of Cortagen Online?
- Visit professional Cortagen supplier Polypeptide.ltd, choose the Cortagen you want to buy.
- Leave your contact and message on polypeptide.ltd website, then submit to polypeptide.ltd.
- The customer service will reply you in 12 hours once received your message, then talk in details about buy Cortagen.
Does Polypeptide.ltd Support The Free Sample Of Cortagen Powder?
It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for sample.
Can I Appoint The Cortagen Colour When Buy Cortagen?
YES! Polypeptide.ltd as a peptide manufacturer, provide colour customization of Cortagen, easy to help you to build your Cortagen peptide brand.
Can I Appoint The Products Standard When Buy Cortagen From Polypeptide.ltd?
YES! As one of the best Cortagen manufacturer, Polypeptide.ltd not only provide the standard specification of Cortagen in 5mg, 10mg, but support standard customization. Provide the best support to build your own Cortagen brand.
Can I Buy Cortagen In Pure Powder Form From Polypeptide.ltd?
YES! Cortagen powder is the base that use for Cortagen lyophilized powder manufacture. Polypeptide.ltd provide Cortagen in both of pure powder form and semi-finished vial form.
Can I Buy Discount Cortagen Powder From Polypeptide.ltd?
YES! Our factory produce high quality Cortagen powder in term and keep
Cortagen powder in stock. You can buy high quality Cortagen powder in bulk. During promotion sale, you can buy Cortagen peptide by lower price. You can keep touch with our customer manager and they will update the latest bulk Cortagen price for you in time.
FAQ
Does Cortagen help to treat Alzheimer’s disease?
Cortagen can stimulate the activity of brain neurons, and has obvious brain protection, metabolic activation and high neurotropic activity. Therefore, Cortagen has a high success rate in treating cognitive impairment, memory and attention difficulties, aphasia, apraxia and mood disorders in patients with vascular dementia. These include Alzheimer’s disease, senile dementia, Parkinson’s and other brain diseases.
Are there any natural sources of Cortagen?
Cortagen is a man-made peptide synthesized. It is not naturally occurring in food or commonly found in the human body. With the development of science and technology and the increasing attention on brain diseases, it is now easy to buy it. Some Cortagen suppliers will sell it online.
Reviews
Cortegen Peptide dosage calculator
Referenced Citations
[1] L. N. Turchaninova, L. I. Kolosova, V. V. Malinin, A. B. Moiseeva, A. D. Nozdrachev, and V. K. Khavinson, “Effect of tetrapeptide cortagen on regeneration of sciatic nerve,” Bull. Exp. Biol. Med., vol. 130, no. 12, pp. 1172–1174, Dec. 2000. [PubMed]
[2] V. K. Khavinson, “Peptides and Ageing,” Neuro Endocrinol. Lett., vol. 23 Suppl 3, pp. 11–144, 2002. [PubMed].
[3] S. V. Anisimov, V. K. Khavinson, and V. N. Anisimov, “Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray,” Neuro Endocrinol. Lett., vol. 25, no. 1–2, pp. 87–93, Apr. 2004.. [PubMed]
[4] V. K. Khavinson, T. A. Lezhava, and V. V. Malinin, “Effects of short peptides on lymphocyte chromatin in senile subjects,”Bull. Exp. Biol. Med., vol. 137, no. 1, pp. 78–81, Jan. 2004, doi: 10.1023/b:bebm.0000024393.40560.05 . [PubMed]
[5] T. Lezhava, J. Monaselidze, T. Kadotani, N. Dvalishvili, and T. Buadze, “Anti-aging peptide bioregulators induce reactivation of chromatin,” Georgian Med. News, no. 133, pp. 111–115, Apr. 2006.. [PubMed]
[6] L. S. Kozina, “Effects of bioactive tetrapeptides on free-radical processes,” Bull. Exp. Biol. Med., vol. 143, no. 6, pp. 744–746, Jun. 2007, doi: 10.1007/s10517-007-0230-8. [PubMed]
[7] T. B. Kazakova et al., “In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes,” Bull. Exp. Biol. Med., vol. 133, no. 6, pp. 614–616, Jun. 2002, doi: 10.1023/a:1020210615148. [PubMed]
[8] S. Korsching “The neurotrophic factor concept: a reexamination” [The Journal of Neuroscience]
[9] D.V. Kurkin et al., “Neuroprotective action of Cortexin, Cerebrolysin and Actovegin in acute or chronic brain ischemia in rats” [PubMed]
[10] Shabanov, Vislobokov “Neuronoprotective action of cortexin and cortagen” [Reviews on Clinical Pharmacology and Drug Therapy]
Author of this article:
Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.Scientific Journal paper Author:
Director of the Saint Petersburg Institute of Bioregulation and Gerontology
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.
Author of this article:
Dr. Jean Zeng graduated from king's college london Faculty of Life Sciences & Medicine.
Scientific Journal paper Author:
Stephen C. Bain
Diabetes Research Group, Swansea University Medical School, Swansea, SA2 8PP, UK
Department of Diabetes and Endocrinology, Singleton Hospital, Swansea Bay University Health Board, Swansea, SA2 8QA, UK
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.
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