Other names:Epithalon, Epithalone, Ala-Glu-Asp-Gly, L-Alanyl-L-glutamyl-L-aspartyl-glycine, UNII-O65P17785G, Epithalamin, Na-epithalon, Na-epithalon-NH2, N-Acetyl Epithalon Amidate
Epitalon peptide is an anti-aging agent and a telomerase activator. Epithalon is the synthetic peptide version of the polypeptide Epithalamin which is naturally produced in the pineal gland. Epitalon main effects is to increase the natural production of telomeres. This allows DNA replication that is important for the formation and regeneration of cells.
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Epithalon, Epithalone, Ala-Glu-Asp-Gly, L-Alanyl-L-glutamyl-L-aspartyl-glycine, UNII-O65P17785G, Epithalamin, Na-epithalon, Na-epithalon-NH2, N-Acetyl Epithalon Amidate
What Is Epithalon?
Epithalon, also known as Epitalon, Epithalone, or Epithalamin, is a short synthetic peptide with the ability to activate the telomerase enzyme and stimulate melatonin release. Originally developed in Russia during the 1980s, Epithalon has demonstrated the ability to delay age-related changes in the reproductive and immune systems, as well as extend the lifespan of mice and rats. While its primary focus is in anti-aging research, Epithalon has also shown promising effects in certain types of cancer, infectious diseases, and DNA regulation. 
History of Peptide Epitalon (Epithalon)
Epitalon, which is also known as Epithalone or Epithalon, is an Epithalamin synthetic version produced naturally in the body. Epitalon peptide was discovered by the Russian scientist Professor Vladimir Khavinson, who then conducted epitalon-related research for the next 35 years in both animal and human clinical trials.
Khavainson had been tasked with finding a way to help military troops heal from battlefield damage. He harvested epithalamin (the natural version of Epitalon) from pineal glands of calves and discovered that certain chains of amino acids known as peptides could regenerate tissue and restore function to various organs and tissues that had fallen into disrepair.
However, since epithalamin was difficult to harvest from animals in large amounts, he found a way to create a synthetic version epitalon, which is widely prescribed today for its anti-aging properties.
According to scientist research, Epithalon peptide has potential uses for neuropathy, slowing the cell ageing process, liver disorders, and geriatrics.
What is Epitalon (Epithalon)?
Epitalon or Epithalon is a peptide that is a synthetic version of an extract called epithalamin. It was discovered in the 1980s by Professor Vladimir Khavinson.
Peptides, the lesser-known siblings of proteins, are chains of amino acids that have garnered significant attention due to their pivotal roles in biological functions. Their smaller size gives them an edge over proteins, offering an easier penetration into cells and thus wider therapeutic implications.
The main use of Epitalon is to boost natural telomerase production in the body. Telomerase is an enzyme that occurs naturally and whose purpose is to protect the DNA. The peptide allows for DNA replication facilitating the growth of new cells through the rejuvenation of damaged or old cells.
Epitalon powder synthesis
Epitalon is considered the “fountain of youth” peptide. It is a tetra-peptide, which means that it is composed of four amino acid chains. The peptide is used to regulate the cell cycle during telomerase activity. Telomerase, also called telomere terminal transferase, is an enzyme made of protein and RNA subunits that elongates chromosomes. When telomerase activity is not present (when we age), our cells age. Our telomeres get shorter and begin to die off. If telomerase is activated in our cells, our telomeres lengthen, the cell continues to grow and divide, delaying the aging process.
Epitalon is synthetic peptide. It is administered as a subcutaneous injection and is available in Polypeptide.ltd in raw powder form and lyophilized powder form.
Epitalone raw powder form
Epitalon powder refers to the active ingredient powdered form of the marketed drug Epitalon 5mg, 10mg, 100mg. Epitalon raw powder is the raw material to produce lyophilized powder Epitalon in vials. It is not ready for individuals to use. Only for research.
Reconstitution(Epitalon finished vials)
Epitalon lyophilized powder form is ready for reconstitution. This lyophilized powder is typically provided in vials or vial kits. The lyophilized powder is then mixed with a suitable diluent, such as bacteriostatic water or sterile water, to create a solution for injection. Reconstitution instructions may vary depending on the specific product and Epitalon peptide manufacturer,so it is important to carefully follow the provided guidelines.
How does Epitalon works丨The Mechanism Of Action Of Epitalon Peptide
Epitalon peptide works in the pineal gland of the brain. Its primary role is to increase the natural production of telomerase, a natural enzyme that helps cells reproduce telomeres, which are the protective parts of our DNA. This allows the replication of our DNA, so the body can grow new cells and rejuvenate old ones. It has shown a 33% increase in telomere length in somatic cells. It has many documented effects on general aging and impacts on the circadian rhythm. It promotes a natural cycle and healthy sleep cycles, it also makes sure that cortisol and other stress hormones are not elevated throughout the day, which can lead to excess abdominal weight gain. It helps regulate levels of melatonin and cortisol. It helps make sure cortisol is elevated in the morning and melatonin is elevated in the evening.
In addition to protecting telomeres from deterioration, Epitalon peptide has been shown to have antioxidant and anti-inflammatory properties that can help reduce cellular damage caused by exposure to environmental toxins or oxidative stressors.
Top 10 Benefits Of Epitalon peptide | What Is Epitalon peptide uses for?
Epitalon peptide has been linked with numerous health benefits. Scientists have conducted many experiments in controlled laboratory environments to show how Epithalon acts as an anti-ageing agent and found multiple benefits of Epitalon use. Here are top 10 benefits of Epitalon peptide use.
①Epitalon Increases lifespan
Younger people produce a relatively large amount of telomerase and longer telomeres. The longer the telomere strands are, the better cell health and replication they provide. However, as people age, the production of telomerase falls and consequently cell replication and health decline. This is the main reason that people age.
Epitalon’s primary role is to increase the natural production of telomerase to increase lifespan. Epitalon peptide well known as “fountain of youth”.
②Epitalon help to improve deep sleep
Epitalon help to improve deep sleep is relate to Melatonin that linked to sleep and aging. Multiple research show that Epitalon peptide affect both the synthesis and release of Melatonin by affecting the expression of two proteins. Both of these genes play an important role in Melatonin production and in the circadian control of Melatonin release. Research in monkeys indicates that Epitalon peptide restores Melatonin secretion to normal.
③Epitalon help to prevents and treats cancer
One of the diseases caused by oxidative stress or free radical damage is cancer. Studies suggest that epitalon’s ability to increase the body’s antioxidant capacity can also help with slowing cancer growth.
The Epitalon effectiveness against cancer is currently still in animal trials, but the results are hopeful for humans. In one study, epithalon treatment slowed the growth of colon cancer in rats by increasing lymph flow and increasing targeted deaths of harmful/useless cells, a method known as apoptosis. It also decreased the maximum size of tumors in mice with mammary tumors. Another study found that mice treated with epitalon did not experience any metastasizing. In other words, the cancer never spread to another part of the body.
④Epitalon and Parkinson’s and Alzheimer’s
Antioxidants get rid of dangerous molecules called free radicals, which are linked to multiple diseases like Parkinson’s and Alzheimer’s. A study in rats found that epitalon increased the total capacity for antioxidants by 36%.
⑤Epitalon help to improve skin health and appearance
Epithalon is undoubtedly a wonder peptide, touching upon every aspect of our biological function. From managing the aging process and metabolic health to optimizing sleep and shaping our genetic expression, this synthetic peptide holds great promise. Its multifaceted roles in our bodies underscore the importance of continued research into understanding and harnessing the power of peptides for therapeutic uses.
Multiple studies show that one of the important Epitalon benefits is that Epitalon help to improve skin health and appearance, due to it has positive effect on the gene that regulates MMP2. MMP2 is a protein found in connective tissue like skin.
⑥Epitalon help to increase the rate of enzymatic activities
Research show that Epitalon peptide help to boosts the protein and sugar-digesting enzymes’ activities.
⑦Epitalon help to improve eyesight
Multiple studies found that epitalon can help combat age-related decline in eye function and other eye disorders. In rats, epithalon administration resulted in improved retinal functionality and preserved its structure. A study showed that epithalon stimulated the proliferation of retinal and pigmented epithelial cells. In patients with degenerative retinal lesions, epithalon therapy produced beneficial effects on visual function.
⑧Epitalon is very safe to use
Research found that it is very safe to use Epitalon peptide. Two 3-year epithalamin treatment trials (one with a 12-year follow-up) reported no severe adverse events in older adults and preclinical studies support a favorable safety profile, but a well-conducted Phase1 safety study and independent validation is needed to confirm safety.
⑨Epitalon neuroprotective benefit
Have not been tested in humans of Epitalon for prevention of cognitive decline, but preclinical studies suggest they may have anti-oxidant activity in the brain and increase melatonin levels.
⑩Epitalon can increase resistance to emotional stress
Studies show that Epitalon can help to increase resistance to emotional stress through multiple methods.
Other Epitalon benefits are:
Improved endocrine process
Strengthened immune system
Better regulated pineal gland function
Improve DNA activation
Epitalon dosage – How to use Epitalon petide?
Epitalon peptide exhibits minimal side effects, low oral and excelletn subcutaneous bioavailability in mice. Per KG Epitalon dosage in mice does not scale to humans. Epitalon for sale at polypeptide.ltd is limited to educational and scientifica resarch use only, not for huamn consumption. Only buy Epitalon peptide if you know it.
Due to the short length of the amino-acidic chain, epithalon is administrated orally, nasal spray drops or injectable (by far the most effective method) in 10 – 20 days-in-row cycles.
Oral administration: 2 – 8 mg/day, 2 – 3 servings per day
Nasal administration: 1 – 5 mg/day, 3 servings per day
Injectable administration: 0.5 – 3 mg/day, 1 – 2 injections per day (intramuscularly or subcutaneously)
When taking Epithalon, or any other phenylethylamine derivative, it’s important to adhere to recommended Epitalon dosage guidelines in order to avoid potential side effects, ensure effectiveness, and monitor your body’s response. It is always recommended to speak with your medical provider before beginning any new protocol or changing your existing one.
Epitalon and GHK-Cu Mix, get better results?
GHK-Cu is a natural peptide in human blood plasma, urine and saliva. Animal studies show that GHK-Cu peptide can improve wound healing, immune function, and skin health by stimulating collagen, fibroblasts, and promoting blood vessel growth. There is evidence that has shown that it acts as a feedback signal that is generated after tissue damage. It also inhibits damage caused by free radicals, making it a powerful antioxidant.
Epitalon is a synthetic peptide that was created on the basis of a natural peptide present in the pineal gland – epithamin. It is a potential modulator of telomerase, an enzyme that maintains and protects telomere caps at the ends of chromosomes (DNA strands). Research suggests that epitalon causes telomere lengthening and may fight the effects of aging as a result.
To optimize its effect, there are many suppliers that sell Epitalon mix with GHK-Cu.
The BPC-157 , as well as the TB500 also shows impressive results, they are not strictly speaking anti-aging but allow tissue regeneration and healing for the BPC-157 and the restoration of veins and arteries for the TB500, BPC-157 and TB 500 for sale on polypeptide.ltd also.
Epitalon side effects and safety
Is it safe to use Epitalon?
Epitalon peptide has many potential benefits for health and well-being, but it can also have negative side effects if not taken in proper dosage. Some of these adverse reactions include nausea, headaches, dizziness and difficulty sleeping. In some cases, users may also experience stomach discomfort, skin rashes and muscle cramps. More serious effects could include hypertension and chest pain. It is important to remember that everyone’s body reacts differently to Epithalon so the intensity of the side effects may vary from person to person. Therefore, it is important to talk to your medical provider before taking this peptide in order to ensure safety when consuming it.
Epitalon powder mixing instructions
The lyophilized powder form of Epitalon is available for reconstitution use. Researchers are encouraged to follow standard peptide reconstitution guidelines when preparing Epitalon for injection use.
What should I have before reconstitution Epitalon?
To correctly reconstitute and inject Epitalon vials, you should have the following on hand:
Vial of lyophilized Epitalon powder
Vial of Bacteriostatic water
Step by Step to reconstitue Epitalon injection:
- Wipe the surfaces of the vial top with alcohol swabs to avoid the incidence of contamination or infection.
- Insert a sterile syringe into the bacteriostatic water vial and withdraw the amount needed based on your dosing protocol. How to calculate the Epitalon powder and bacteriostatic water dosage? You can use the “Peptide Dosage Calculator”that provide by Polypeptide.ltd.
- slowly inject the bacteriostatic water into the Epitalon vial, allowing it to trickle down the side and gradually dissolving the epitalon powder.
- Avoid shaking or stirring the Epitalon vial, as this can affect the peptide;s integrity.
- Store any leftover solution in refrigeator
How to store Epitalon peptide?
During the initial research stages, researchers work on the Epitalon peptide in lyophilished powder form. It is then diluted in water or a mild acetic acid solution during the course of the experiment. In its original form, it can last for about three months in room temperature and should be kept at four degrees centigrade once it is diluted. The peptide can be safely used for research for 2-21 days (to lengthen its shelf life, store it at -18 Degrees Centigrade).
Epitalon for sale | Where to buy Epitalon peptide
Are you interested in trying to reduce the affects of aging? Epithalon, also known as Epitalon, is a peptide that has been linked to anti-aging properties. It’s gaining popularity in health and wellness circles for its potential to help reduce cellular aging, improve sleep quality, and enhance overall well-being.
However, as technology continues to mature, more and more peptide manufacturer such as Polypeptide.Ltd and research companies can synthesize Epitalon powder by their independent lab. Epitalon powder is primarily available in the form of synthetic peptide. There are many Epitalon for sale online now, finding a reliable source to buy Epitalon powder can be a challenging task. Researchers who are interested in experimenting with Epitalon powder will want to ensure that they source this material from a reliable supplier. lf you’re looking to buying Epitalon powder online, Polypetide.Ltd will be the one of Epitalon manufacturers you don’t want to miss. And buy Epitalon peptide powder bulk will get a good price.
Epithalon is a peptide used to regulate the cell cycle through up-regulation of telomerase activity. The sequence of amino acids in the Epitalon peptide is Alanine-Glutamate-Asparagine-Glycine. Animal studies have been done on the effects of Epithalon on suppression of spontaneous mammary tumors and spontaneous carcinogenesis. Studies have shown that the mode of action of Epithalon involves suppression of oncogene expression and modification of telomerase activity.
Polypeptide.ltd as a peptide powder manufacturer, supply Epitalon peptide both in raw powder form and lyophilized powder vial form. If you are looking for buying Epitalon powder or semi-finish vial, here is the right place you are. No matter small quantity or bulk order, you can get the best Epitalon price support.
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Where to buy affordable Epitalon powder or Epitalon lyophilized powder vial? You can choose to find Epitalon suppliers online.
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- Visit professional Epitalonsupplier Polypeptide.ltd, choose the Epitalon vials you want to buy.
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Does Polypeptide.ltd Support The Free Sample Of Epitalon Powder?
It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for sample.
Can I Appoint The Epitalon Colour When Buy Epitalon?
YES! Polypeptide.ltd as peptide manufacturer, provide colour customization of Epitalon, easy to help you to build your Epitalon peptide brand.
Can I Appoint The Products Standard When Buy Epitalon From Polypeptide.ltd?
YES! As one of the best Epitalon manufacturer, Polypeptide.ltd not only provide the standard specification of Epitalon in 5mg, 10mg, but support standard customization. Provide the best support to build your own Epitalon brand.
Can I Buy Epitalon In Pure Powder Form From Polypeptide.ltd?
YES! Epitalon powder is the base that use for Epitalon lyophilized powder manufacture. Polypeptide.ltd provide Epitalon in both of pure powder form and semi-finished vial form.
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YES! Our factory produce high quality Epitalon powder in term and keep Epitalon powder in stock. You can buy high quality Epitalon powder in bulk. During promotion sale, you can buy Epitalon peptide by lower price. You can keep touch with our customer manager and they will update the latest bulk Epitalon price for you in time.
What Is The Function Of Epitalon peptide?
Epitalon’s primary role is to increase the natural production of telomerase, a natural enzyme that helps cells reproduce telomeres, which are the protective parts of our DNA. This allows the replication of our DNA so the body can grow new cells and rejuvenate old ones.
What is the difference between epitalon and Epithalamin?
What is it? Epithalamin (sometimes spelled “epithalamine”) is a crude polypeptide extract of bovine pineal glands while epithalon (also spelled “epitalon”) is a tetrapeptide isolate (Ala-Glu-Asp-Gly) from epithalamin that can also be made synthetically.
What peptides lengthen telomeres?
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.
How does peptide epitalon activate chromatin at the old age?
Conclusions: Epitalon has shown its ability to activate chromatin by modifying heterochromatin and heterochromatinized chromosome regions in the cells of older persons.
Does epitalon peptide increase testosterone?
It is critical to understand that epitalon is not a hormone, but rather a synthetic peptide that mimics the effects of the natural hormone epithalamine. As a result, it may indirectly affect testosterone levels by promoting the health and function of the pituitary gland, which regulates hormone synthesis.
Does Epitalon help sleep?
Epitalon has been called the “fountain of youth” peptide because of its rejuvenating effects. Our patients have also benefited from better sleep and reduced stress with regular Epitalon treatment.
What is the effect of epitalon?
In human clinical studies, epitalon and epithalamin both significantly increased telomere lengths in the blood cells of patients of ages 60-65 and 75-80, and their efficacy was comparable to one another. Epitalon and epithalamin appear to restore melatonin secretion by the pineal gland in both aged monkeys and humans.
Epithalon Peptide dosage calculator
 V. N. Anisimov, S. V. Mylnikov, and V. K. Khavinson, “Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats,” Mech. Ageing Dev., vol. 103, no. 2, pp. 123–132, Jun. 1998. [PubMed]
 V. K. Khavinson, I. E. Bondarev, and A. A. Butyugov, “Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells,” Bull. Exp. Biol. Med., vol. 135, no. 6, pp. 590–592, Jun. 2003. [PubMed].
 T. A. Dzhokhadze, T. Z. Buadze, M. N. Gaiozishvili, M. A. Rogava, and T. A. Lazhava, “[Functional regulation of genome with peptide bioregulators by hypertrophic cardiomyopathy (by patients and relatives)],” Georgian Med. News, no. 225, pp. 94–97, Dec. 2013. [PubMed]
 V. N. Anisimov et al., “Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice,” Biogerontology, vol. 4, no. 4, pp. 193–202, 2003. [PubMed]
 V. K. Khavinson, S. I. Tarnovskaya, N. S. Linkova, V. E. Pronyaeva, L. K. Shataeva, and P. P. Yakutseni, “Short cell-penetrating peptides: a model of interactions with gene promoter sites,” Bull. Exp. Biol. Med., vol. 154, no. 3, pp. 403–410, Jan. 2013. [PubMed]
 N. S. Lin’kova, B. I. Kuznik, and V. K. Khavinson, “[Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging],” Adv. Gerontol. Uspekhi Gerontol., vol. 25, no. 3, pp. 478–482, 2012. [PubMed]
 N. I. Chalisova, N. S. Lin’kova, A. N. Zhekalov, A. O. Orlova, G. A. Ryzhak, and V. K. Khavinson, “[Short peptides stimulate skin cell regeneration during ageing],” Adv. Gerontol. Uspekhi Gerontol., vol. 27, no. 4, pp. 699–703, 2014. [PubMed]
Scientific Journal paper Author:
Stephen C. Bain
Diabetes Research Group, Swansea University Medical School, Swansea, SA2 8PP, UK
Department of Diabetes and Endocrinology, Singleton Hospital, Swansea Bay University Health Board, Swansea, SA2 8QA, UK
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.