Other names:Growth Hormone-Releasing Peptide-6, GHRP VI
GHRP-6 peptide is a hexapeptide composed of L-amino acids and D-amino acids. The main role of GHRP-6 peptide is to promote food consumption by inducing hunger and improving energy metabolism, so as to achieve the purpose of increasing muscle and reducing fat. It is also widely used to treat growth hormone deficiency and other complications such as obesity and eating disorders. In addition, the reason GHRP-6 peptide is superior to other GHRPs is its effect on increasing appetite (which can also be a drawback), and it has proven its value in reducing inflammation and helping to heal injuries, especially tendinitis.
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Growth Hormone Releasing Peptide 6, Hexapeptide-2, HWAWFK-NH2, SKF 110679, U 75799E
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GHRP-6 Peptide dosage calculator
Cabrales A, Gil J, Fernández E, Valenzuela C, Hernández F, García I, Hernández A, Besada V, Reyes O, Padrón G, Berlanga J, Guillén G, González LJ (2013). “Pharmacokinetic study of Growth Hormone-Releasing Peptide 6 (GHRP-6) in nine male healthy volunteers”. Eur J Pharm Sci. 48(1–2): 40–6. doi:10.1016/j.ejps.2012.10.006. PMID 23099431.
Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB (2004). “Ghrelin–a hormone with multiple functions”. Frontiers in Neuroendocrinology. 25 (1): 27–68. doi:10.1016/j.yfrne.2004.03.002. PMID 15183037. S2CID 24821233.
Peñalva, A; Carballo, A; Pombo, M; Casanueva, FF; Dieguez, C (1993). “Effect of growth hormone (GH)-releasing hormone (GHRH), atropine, pyridostigmine, or hypoglycemia on GHRP-6-induced GH secretion in man”. The Journal of Clinical Endocrinology and Metabolism. 76 (1): 168–71. doi:10.1210/jcem.76.1.8421084. PMID 8421084.
Camanni, F; Ghigo, E; Arvat, E (1998). “Growth hormone-releasing peptides and their analogs”. Frontiers in Neuroendocrinology. 19 (1): 47–72. doi:10.1006/frne.1997.0158. PMID 9465289. S2CID 31400577.
Adeghate, E; Ponery, AS (2002). “Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats”. Journal of Neuroendocrinology. 14 (7): 555–60. doi:10.1046/j.1365-2826.2002.00811.x. PMID 12121492. S2CID 26490804.
McGirr, R; McFarland, MS; McTavish, J; Luyt, LG; Dhanvantari, S (2011). “Design and characterization of a fluorescent ghrelin analog for imaging the growth hormone secretagogue receptor 1a”. Regulatory Peptides. 172 (1–3): 6976doi:10.1016/j.regpep.2011.08.011. PMID 21893106. S2CID 8213917.
Koh, B., & Hardie, M. (2013). We need an advocate against ASADA’s power in doping control. Retrieved from https://theconversation.edu.au/we-need-an-advocate-against-asadas-power-in-doping-control-12119
The growth hormone secretagogue receptor: its intracellular signaling and regulation.Yin Y, Li Y, Zhang W.Int J Mol Sci. 2014 Mar 19;15(3):4837-55. doi: 10.3390/ijms15034837.PMID: 24651458
Ghrelin receptors in non-Mammalian vertebrates.Kaiya H, Kangawa K, Miyazato M.Front Endocrinol (Lausanne). 2013 Jul 17;4:81.doi:10.3389/fendo .2013.00081. eCollection 2013.PMID: 23882259
Mear Y, Enjalbert A, Thirion S.Front Neurosci. 2013 May 29;7:87. doi: 10.3389/fnins.2013.00087. eCollection 2013.PMID: 23754971
GHRP-6 induces CREB phosphorylation and growth hormone secretion via a protein kinase Csigma-dependent pathway in GH3 cells.Tian C, Ye F, Xu T, Wang S, Wang X, Wang H, Wan F, Lei T.J Huazhong Univ Sci Technolog Med Sci. 2010 Apr;30(2):183-7. doi: 10.1007/s11596-010-0210-5. Epub 2010 Apr 21.PMID: 20407870
The effect of GHRH, GHRP-2 and somatostatin on GH secretion by fetal pituitary.Liu Q, Bai X, Liu K, Lin W, Lei T.J Tongji Med Univ. 1999;19(4):277-9. doi: 10.1007/BF02886962.PMID: 12938517
Popovic V, Leal A, Micic D, et al. GH-releasing hormone and GH-releasing peptide-6 for diagnostic testing in GH-deficient adults. Lancet. 2000;356(9236):1137-1142.
Ilson BE, Jorkasky DK, Curnow RT, Stote RM. Effect of a new synthetic hexapeptide to selectively stimulate growth hormone release in healthy human subjects. Journal of Clinical Endocrinology & Metabolism. 1989;69(1):212-214.
Alaioubi B, Mann K, Petersenn S. Diagnosis of growth hormone deficiency in adults: provocative testing with GHRP6 in comparison to the insulin tolerance test. Hormone & Metabolic Research.2009;41(3):238-243.
What Is GHRP-6?
GHRP-6 is a potent stimulator of natural Growth Hormone Release from the anterior pituitary gland. It acts as an agonist of the ghrelin/growth hormone receptor and is among a few ghrelin analogues that have been developed in recent decades. Research has shown that GHRP-6 exhibits beneficial effects on various aspects, including heart muscle cells, memory formation, scar formation, sex motivation, and the neurons associated with Parkinson’s disease.
One notable advantage of GHRP-6 is its oral and sublingual activity, allowing for convenient administration. Additionally, it demonstrates moderate to high selectivity for its target receptors.
Molecular Formula: C4HsN12Oo
Molecular Weight: 873.032 g/mol
PubChem CID: 9919153
CAS Number: 87616-84-0
1. Improves Memory
The relationship between physical activity and learning/memory formation has been a subject of ongoing research. While the precise mechanism has yet to be fully elucidated, there has consistently been evidence suggesting that physical activity enhances cognition and learning, especially when exercise is performed immediately after a learning task.
Initially, the cognitive benefits of exercise were attributed to enhanced blood flow and general references to growth hormone (GH). However, research conducted on rodents has shed light on the potential significance of GH in memory formation. Specifically, studies have shown that GHRP-6, a ghrelin analog, can contribute to the consolidation of newly formed memories and the conversion of short-term memories into long-term storage. Additionally, compelling evidence supports the involvement of ghrelin/GHRP-6 in spatial learning tasks. These findings suggest that the cognitive advantages resulting from exercise may be mediated through growth hormone secretagogues like ghrelin, and that the impact of GH may be indirect and potentially secondary to the actions of these peptides.
2. Protects Brain Tissue
Animal models of stroke are employed to study the potential of GHRP-6 in shielding neurons and other cells in the central nervous system against the detrimental effects of inadequate blood supply. It has been discovered that GHRP-6 not only provides protection to brain tissue during acute stroke but also has the ability to restore memory deficits after a stroke when the peptide is administered in a timely manner. It appears that ghrelin and its analogues inhibit apoptosis (programmed cell death) and alleviate inflammation in the brain, safeguarding neurons from both genetic factors and the surrounding environment in the aftermath of a stroke.
Pathway by which ghrelin inhibits apoptosis and reduces inflammation.
3. Protects Parkinson’s Neurons
Our understanding of the neuroprotective effects of GHRP-6 has been enhanced by a study conducted in 2018, which revealed the presence of ghrelin receptors in the substantia nigra, a brain region affected by Parkinson’s disease. Individuals with genetic predisposition to Parkinson’s disease exhibit reduced expression of ghrelin receptors on substantia nigra neurons. Furthermore, when an antagonist is injected into rats with the same receptor defect, they display Parkinson’s symptoms. It is logical to speculate that agonists such as GHRP-6 may have potential applications in Parkinson’s disease. Scientists propose that the peptide, by binding to the diminished receptors, may attenuate apoptosis in substantia nigra neurons, potentially slowing down or even preventing the onset of Parkinson’s disease.
4. Improves Skin Appearance and Reduces Scaring
GHRP-6 enhances cell survival by inhibiting programmed cell death in various cell types. Additionally, the peptide interacts with the CD36 receptor, which plays a role in promoting angiogenesis, especially in wound healing. Studies conducted in rats suggest that these characteristics make GHRP-6 highly beneficial in wound healing processes. It accelerates wound closure, enhances the production of extracellular matrix proteins such as collagen, and disrupts the typical scar formation process, thereby improving overall tissue organization and reducing the visibility of scar tissue at the wound site.
The peptide has also demonstrated the ability to inhibit the formation of hypertrophic scars. Hypertrophic scars, similar to keloids, occur due to abnormal deposition of extracellular matrix proteins. GHRP-6 effectively prevents this process, providing significant benefits to individuals affected by this abnormal healing response. Consequently, people often delay undergoing surgeries and other medical procedures to minimize the development of painful scars and the resulting noticeable changes in appearance.
5. Reduces Heart Problems
Research conducted in porcine models of myocardial infarction demonstrates that GHRP-6 exhibits the ability to prevent oxidant cytotoxicity. In other words, the peptide effectively safeguards cardiac cells from damage caused by free radicals.
6. Alters Sex Motivation and Mood
Research conducted in male rats suggests that ghrelin receptors in the central nervous system play a role in regulating sexual behavior and motivation. Increased levels of ghrelin have been found to enhance sexual motivation. Studies involving GHRP-6 and a modified version of GHRP-6 designed to antagonize the ghrelin receptor have provided evidence that ghrelin receptors in specific brain regions contribute to the modulation of sexual behavior and reward-seeking behavior. These findings have implications not only for understanding sexual desire disorders, but also for hunger regulation and other forms of motivation.
There is also evidence suggesting that ghrelin may influence mood in addition to its impact on motivation. Studies conducted in mice have shown that GHRP-6 and other ghrelin receptor agonists can reduce depression and enhance the function of brain regions associated with mood, especially under conditions of stress. This indicates that GHRP-6 could serve as a basis for further research into potential innovative treatments for stress, anxiety, depression, and other mood disorders.
GHRP-6 demonstrates minimal to moderate side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. However, it is important to note that dosage per kilogram in mice does not directly translate to humans. GHRP-6 available for purchase at Peptide Sciences is strictly intended for educational and scientific research purposes, and not for human consumption. Therefore, it is advised to only acquire GHRP-6 if you possess a valid research license.
 C.-C. Huang, D. Chou, C.-M. Yeh, and K.-S. Hsu, “Acute food deprivation enhances fear extinction but inhibits long-term depression in the lateral amygdala via ghrelin signaling,”Neuropharmacology, vol. 101, pp. 36–45, Feb. 2016.
 S. Beheshti and S. Shahrokhi, “Blocking the ghrelin receptor type 1a in the rat brain impairs memory encoding,” Neuropeptides, vol. 52, pp. 97–102, Aug. 2015.
 K. Tóth, K. László, and L. Lénárd, “Role of intraamygdaloid acylated-ghrelin in spatial learning,” Brain Res. Bull., vol. 81, no. 1, pp. 33–37, Jan. 2010.
 Structure–activity relationships of GHRP-6 azapeptide ligands of the CD36 scavenger receptor by solid-phase submonomer azapeptide synthesis [pubs.acs.org]
 S. J. Spencer, A. A. Miller, and Z. B. Andrews, “The Role of Ghrelin in Neuroprotection after Ischemic Brain Injury,” Brain Sci., vol. 3, no. 1, pp. 344–359, Mar. 2013. [PubMed]
 Y. Suda et al., “Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson’s disease-like motor dysfunction,” Mol. Brain, vol. 11, no. 1, p. 6, 20 2018. [PubMed]
 Y. Mendoza Marí et al., “Growth Hormone-Releasing Peptide 6 Enhances the Healing Process and Improves the Esthetic Outcome of the Wounds,” Plastic Surgery International, 2016. [Online]. Available: [Accessed: 23-May-2019]
scientific journal paper author:
National Center for International Research on Animal Gut Nutrition, Nanjing Agricultural University, 210095 Nanjing, China
Aquatic Biotechnology Project, Center for Genetic Engineering and Biotechnology, Havana, Cuba
Department of Plant and Animal Biology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
Quality Assurance Unit, Center for Genetic Engineering and Biotechnology, PO Box 6162, Havana, Cuba
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.