Pinealon
Other names:Glutamylaspartylarginine, T-33 peptide
Pinealon synthetic peptide is an interesting molecule that has gained popularity for boosting central nerve function. Its vast study on its capacity to boost memory and counterbalance the effects of aging has caught the interest of the anti-aging community. It may be beneficial in the treatment of cognitive diseases such as Alzheimer’s disease. It has the potential to change how we think about cognitive performance, aging, and general brain health. Let’s learn more about pinealon peptide!
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Sequence: | Glu-Asp-Arg |
Molecular Formula: | C15H26N6O8 |
Molecular Weight: | 418.407 g/mol |
PubChem CID: | 18220191 |
CAS Number: | 175175-23-2 |
Synonyms: | Glutamylaspartylarginine, T-33 peptide |
Pinealon Structure
Authoritative source：PubChem
What Is Pinealon Peptide
Peptide Pinealon is a synthetic peptide that interacts with DNA to alter gene expression levels. It aids in the protection of several cell types, including neurons and others. It possesses the shortest and most active peptide chain, consisting of only three amino acids (arginine, glutamic acid, and aspartic acid), and it protects against hypoxia.[1]
According to cell culture testing, pinealon directly infiltrates both nuclear and cell membranes to work with DNA. By affecting the pineal gland, located in the epithalamus, Pinealon peptide can help alleviate problems of drug metabolism, cognitive disorders, and many others.
The pineal gland controls the day and night cycle, as well as the body’s daily rhythms, as well as infertility, growth, aging, and puberty. It also generates melatonin and Epitalon.
Pinealon is considered to help with peptide insufficiency by boosting protein synthesis. The Pinealon delivers amino acids to the brain tissues, which directly impact the DNA structure of brain cells.[2]
Pinealon amino acids repair the protein that keeps cells together by replacing outdated or damaged molecules in the DNA structure. Normal brain function is given by the rebuilt DNA structure.[15]
As previously stated, Pinealon peptide is a man-made molecule being researched for potential health purposes. This medicine is extracted from the growing brains of animals.
What are the benefits of Pinealon peptide?
Pinealon and Anti-Aging
Pinealon and other peptides have anabolic effects on the brain, which helps to reduce the indications of aging, according to research findings. Pinealon also exerts impacts on muscle cells by modulating irisin expression, according to research.
Irisin protects muscle cells during severe workouts and activities, aids in fat burning, and promotes telomere extension. Pinealon combats oxidative damage and aging by increasing the lifetime of irisin.[3][4]
Pinealon and Sleep
Pinealon’s benefit include influencing both sleep and waking behavior. According to research, it aids in the regulation of dysfunction caused by activities such as traveling, shift work, and others that disrupt the usual sleep cycle. Inadequate sleep has an impact on mood, heart health, cognition, wound healing, and other physiological processes. Pinealon can assist to reduce the consequences of poor sleep and counteract the aging process.
Pinealon and Depression
Pinealon peptide has been shown in studies on brain cortex cells to modify epigenetics and boost 5-tryptophan hydroxylase. The enzyme 5-tryptophan hydroxylase makes it difficult to manufacture and release serotonin. SSRIs (selective serotonin reuptake inhibitors) antidepressants also target the signaling molecule. This medication has a number of adverse effects; however, by increasing serotonin levels, pinealon therapy can aid with depression and anxiety problems while also reducing unwanted effects.
Pinealon and Brain Protection
Pinealon has been shown in animal experiments to protect neurons against oxidative damage. It can protect cognitive function and motor coordination in this way. According to a few studies, rats reduced the buildup of oxygen species and the number of necrotic cells.[5][6]
As a result, the peptide protects neurons against deprivation. It also activates proliferation pathways, altering the cell cycle and reducing the damaging effects of oxygen species.
Pinealon and Heart Health
Caspase-3 is important not just in neurological tissues, but also in apoptosis. According to recent research, elevated caspase-3 levels in the blood remain after a myocardial infarction. Thus, the fact that enzyme control can aid to preserve cardiac tissues suggests that pinealon can guard the circulatory system after a heart attack.[13][14]
Further research revealed that pinealon can improve the stability of the red blood cell membrane by preventing lipid peroxidation. Pinealon can reverse the buildup of atherosclerotic plaque and prevent heart attack and heart disease by lowering lipid peroxidation.
Pinealon and Skin Health
Pinealon can decrease caspase-3 in skin cells while also promoting cell proliferation in both aged and young animals. As a result, it reverses age-related skin disease and boosts the regeneration process. It can assist with a variety of skin conditions, including severe burns and more.[7][8]
Pinealon is the most effective peptide for treating a variety of health issues, including brain illnesses and anxiety disorders. Furthermore, researchers believe that taking it is safe because it has less adverse effects.
Pinealon side effects and safety
Headaches and nausea are the most prevalent adverse effects of Pinealon. These adverse effects are often minor and resolve on their own.
Please cease usage and see a health care expert if you suffer severe or persistent adverse effects.
Pinealon is a very efficient peptide with several advantages for individuals who take it carefully and under expert supervision.
Pinealon vs Epithalon
Epithalon and Pinealon share the property of being telomerase-stimulating peptides.
Pinealon peptide has been demonstrated to be more beneficial than Epitalon peptide in terms of raising energy levels, enhancing cognitive function, and encouraging memory recall.
Pinealon also has a lower risk of causing adverse effects such as headaches and nausea. For individuals seeking for an anti-aging peptide, Pinealon is the preferable option.[9][10]
(Note: Read also about Epithalon)
Pinealon For Sale | Pinealon supplier
Pinealon is recommended for everyone whose brain may be compromised, especially elderly people and those with poor memory, attention difficulties, brain injury, stroke, brain surgery, high stress, chronic fatigue, depression, insomnia, irritability or diseases. It also helpful for people whose professional activity requires full attention. Researchers interested in experimenting with Pinealon will want to ensure that they source this material from a reliable peptide supplier. lf you’re looking to buying Pinealon online, it is essential to exercise caution and ensure that you obtain the peptide from a reputable and trustworthy manufacuturer. Polypeptide.Ltd is a highly reliable manufacturer that offers pharmaceutical grade peptides.[11][12]
Pinealon is a fascinating compound that has the potential to revolutionize our understanding of cognitive function, aging, and overall brain health. If you are looking for the professional and top peptide Pinealon manufacturer or factory, here is the right place where you are.
Being an important and famous anti aging drug, Pinealon plays an important role in the regulation of sleep, depression, heart health and longevity. It has been reported that Pinealon is a kind of exercise-induced mitochondrial coding regulator, and the level of Pinealon in skeletal muscle and blood of mice decreases with age.
As the best Pinealon peptide manufacturer, Polypeptide.ltd is not only supply the peptide Pinealon in powder form but provide the customized standard easy use vial form.
You can buy the best price Pinealon and best quality peptide from this professional peptide manufacturer.
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Polypeptide.ltd as a peptide factory, is the best place where you can buy Pinealon in compeptitive price, from small to bulk quantity. Click and make a contact, you will get all the details. Before buy Pinealon, you may curious:
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Does Polypeptide.ltd Support The Free Sample Of Pinealon Powder?
It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for sample.
Can I Appoint Colour When Buy Pinealon Peptide?
YES! Polypeptide.ltd as peptide manufacturer, provide colour customization of Pinealon, easy to help you to build your Pinealon peptide brand.
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YES! As one of the best Pinealon manufacturer, Polypeptide.ltd not only provide the standard specification of Pinealon in 5mg, 10mg, but support standard customization. Provide the best support to build your own Pinealon brand.
Can I Buy Pinealon In Pure Powder Form From Polypeptide.ltd?
YES! Pinealon powder is the base that use for Pinealon lyophilized powder manufacture. Polypeptide.ltd provide Pinealon in both of pure powder form and semi-finished vial form.
Can I Buy Discount Pinealon Powder From Polypeptide.ltd?
YES! Our factory produce high quality Pinealon powder in term and keep Pinealon in stock. You can buy high quality Pinealon powder in bulk. During promotion sale, you can buy Pinealon peptide by lower price. You can keep touch with our customer manager and they will update the latest bulk Pinealon price for you in time.
What is the Pinealon peptide?
The Pinealon peptide is a nootropic peptide produced from pineal gland proteins. It’s been connected to possible advantages including cognitive boosting and maybe reducing the aging process.
Who Can Take Pinealon?
Pinealon is recommended for persons who struggle with focus, memory, stress, depression, neuritis, insomnia, brain damage, multiple sclerosis, and other health conditions. It also assists people who require undivided focus to fulfill their professional responsibilities.
Is Pinealon safe?
According to current studies, Pinealon is reasonably safe. However, before beginning any new supplement or therapy, always discusss with doctor.
Does the Pinealon peptide have any side effects?
Like any compound, the Pinealon peptide may have side effects. But so far, it appears to be well-tolerated in research settings.
Is Pinealon worth the money?
Pinealon is one of the most effective peptides on the market. It is definitely worth the money for those looking for an anti-aging solution.
What other research chemicals function similarly to Pinealon peptide?
Both Epithalon and Pinealon have the property of activating telomerase. Pinealon is thought to be more effective than Epithalon at boosting energy, improving cognitive function, and promoting memory recall.
Pinealon Peptide dosage calculator
Referenced Citations
[1] Khavinson V, et al. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Res. 2011 Oct;14(5):535-41.
[2] G. V. Karantysh, et al. Effect of Pinealon on Learning and Expression of NMDA Receptor Subunit Genes in the Hippocampus of Rats with Experimental Diabetes. Neurochemical Journal, 2020, 14, 314-320.
[3]Arutjunyan A, et al. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. Int J Clin Exp Med. 2012;5(2):179-85.
[4]L. l. Fedoreyeva, l. l. Kireev, V.K. Khavinson, and B. F. Vanyushin, “Penetration ofshort fluorescence-labeled peptides into the nucleus in HeLa cells and in vitrospecific interaction of the peptides with deoxyribooligonucleotides and DNA,” Biochem. Biokhimiia, vol. 76, no. 11, pp. 1210-1219, Nov. 2011.
[5]V. N. Meshchaninov, E. L.Tachenko, S. V. Zharkov, l. V. Gavrilov, and I. E. Katyreva,“[EFFECT OF SYNTHETICPEPTIDES ON AGING OF PATIENTS WITH CHRONICPOLYMORBIDITY AND ORGANIC BRAIN SYNDROME OFTHE CENTRAL NERVOUS SYSTEM IN REMISSION],”Adv. Gerontol. Uspekhi Gerontol., vol. 28, no.1, pp. 62-67,2015
[6]V. K. Khavinson, B. I. Kuznik, S.I. Tarnovskaya, and N. S. Lin’kova, “Short Peptides and Telomere Length RegulatorHormone lrisin,” Bull. Exp. Biol. Med., vol. 160, no. 3, pp. 347-349, Jan. 2016.
[7]A. Arutjunyan, L. Kozina, S. Stvolinskiy, Y Bulygina, A. Mashkina, and V. Khavinson, “Pinealon protects the rat offspring from prenatal hyperhomocysteinemia,” Int. J. Clin.Exp.Med., vol. 5, no. 2, pp. 179-185, 2012
[8]A. M. Mendzheritskir, G. V. Karantysh, G. A Ryzhak, and S. V. Demianenko, “[Regulation of content of cytokines in bloodserum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon],”Adv.Gerontol. Uspekhi Gerontol., vol. 27, no.1, pp. 94-97, 2014.
[9] Khavinson, VKh; Bondarev, IE; Butyugov, AA (2003). Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 135 (6): 590–592. doi:10.1023/a:1025493705728. PMID 12937682. S2CID 7762518.
[10]YKozina, LS; Arutjunyan, AV; Khavinson, VKh (2007). “Antioxidant properties of geroprotective peptides of the pineal gland”. Arch Gerontol Geriatr. 44: 213–216.
[11]Khavinson, VKh; Lin’kova, NS (2012). “Morphofunctional and molecular bases of pineal gland aging”. Fizol Cheloveka. 38 (1): 119–127. PMID 22567846.
[12]Khavinson, VKh (2002). “Peptides and aging”. Neuro Endocrinol Lett. 23 (3): 11–144. PMID 12374906.
[13]Khavinson, VKh; Bondarev, IE; Butyugov, AA; Smirnova, TD (2004). “Peptide promotes overcoming of the division limit in human somatic cell”. Bull Exp Biol Med. 137 (5): 503–506. doi:10.1007/s10517-016-3370-x. PMID 15455129. S2CID 13941652.
[14] Khavinson, VKh; Lezhava, TA; Monaselidze, JR; Jokhadze, TA; Dvalishvili, NA; Bablishvili, NK; Trofimova, SV (2003). “Peptide Epitalon activates chromatin at the old age”. Neuro Endocrinol Lett. 24 (5): 329–333. PMID 14647006.
[15]Korkushko, OV; Khavinson, VKh; Shatilo, VB; Antonuk-Sheglova, IA (2006). “Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging”. Bull Exp Biol Med. 142 (3): 356–359. doi:10.1007/s10517-006-0365-z. PMID 17426848. S2CID 31963683.
Author of this article:
Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.
scientific journal paper author:
1.Michael M. McDowell
Division of Neurological Surgery, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
2.Vladimir Kh. Khavinson
St. Pertersburg Institute of Bioregulation and Gerontology, 3 prosp. Dynamo, St. Petersburg, 197110, Russia
3.L.K. Obukhova
N.M. Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, 4 Kosygin Street, Moscow 117977, Russia
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.
Author of this article:
Dr. Jean Zeng graduated from king's college london Faculty of Life Sciences & Medicine.
Scientific Journal paper Author:
Stephen C. Bain
Diabetes Research Group, Swansea University Medical School, Swansea, SA2 8PP, UK
Department of Diabetes and Endocrinology, Singleton Hospital, Swansea Bay University Health Board, Swansea, SA2 8QA, UK
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.
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