pralmorelin（GHRP-2）
Other names: Pralmorelin, Growth Hormone Releasing Peptide-2, GHRP-2, KP102.
GHRP-2(Growth Hormone Releasing Peptide-2) from Polypeptide.ltd is a synthetic hexapeptide Growth Hormone Releasing Peptide (GHRP) that acts on the brain and pituitary gland to produce growth hormone while also having a minor stimulatory effect on Prolactin, ACTH, and Cortisol levels. GHRP-2 is a real hGH secretagogue, which means it stimulates the body’s own hGH secretion. In research, human growth hormone has been proven to improve lean body mass and minimize adiposity (fat). GHRP-2 has been shown to be highly effective at stimulating GH production in research test subjects.
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Properties
Sequence: | H-D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2 |
Molecular Formula: | C45H55N9O6 |
Molecular Weight: | 817.99g/mol |
PubChem CID: | 6918245 |
CAS Number: | 158861-67-7 |
Synonyms: | Growth Hormone Releasing Peptide-2, GHRP-2, KP102, Pralmorelin |
Description
MOTS-C Structure
Authoritative source：PubChem
What is Growth Hormone Releasing Peptide-2 (GHRP-2)?
Growth Hormone Releasing Peptide-2 (GHRP-2), the CAS number is 158861-67-7, it also known as Pralmorelin, KP102, It was created in a lab like the natural peptide ghrelin, first extracted from the stomach, the naturally occurring peptide ghrelin is made of 28 amino acids, it’s a synthetically made growth hormone secretagogue, a peptide that stimulates the body to increase natural production of growth hormone. GHRP-2 is also an agonist of ghrelin, a gut peptide and also known as “the hunger hormone”, which binds to the growth hormone secretagogue receptor. So, peptide GHRP2 has demonstrated that it is very effective at controling hunger, growth hormone production, and tissue repair.[1]
Noted: that the abbreviation GHRP-2 will be used instead of Growth Hormone Releasing Peptide-2 below to explore more about the effects, working mechanism of the peptide, side effects and more.
How does Peptide GHRP-2 Works?
Peptide GHRP-2 works in two ways to boost natural growth hormone synthesis. First, the GHRP-2 enhances the natural growth hormone releasing signal, resulting in significant growth hormone secretion. Second, it lowers somatostatin, also known as growth hormone inhibiting hormone (GHIH) in the body. Somatostatin causes the body to produce less natural growth hormone. GHRP-2 can boost growth hormone production by inhibiting somatostatin activity, resulting in higher natural growth hormone levels. GHRP-2 also stimulates the production of ghrelin, a peptide hormone generated in the gastrointestinal tract that has a profound effect on growth hormone production and appetite.[2][3]
Because GHRP-2 stimulates the body to produce growth hormone, there is no interruption in natural growth hormone production as with synthetic hGH treatment. Instead of being constantly increased, peptide GHRP-2 promotes growth hormone secretion in a manner that closely reflects natural release patterns. This technique avoids many of the unfavorable side effects associated with synthetic hGH administration, such as the cessation of natural growth hormone production.
What is the Potential Effects of GHRP-2?
❶ Protects and improves muscle structure
According to Yak research, GHRP-2 can promote muscle growth in two ways: enhanced protein deposition and decreased protein breakdown. The study found that GHRP-2 can overcome natural development plateaus in yaks caused by food scarcity, sickness, and harsh climatic conditions (such as cold). The most significant discovery of this study is that GHRP-2 inhibits muscle atrophy by inactivating the proteins atrogin-1 and MuRF1, which govern the muscle degradation pathway. These discoveries have the potential to be utilized to minimize catabolism, which is widespread in chronic conditions such as autoimmune disease, cancer, and others. Of course, GHRP-2 promotes muscle protein deposition by activating growth hormone and insulin-like growth factor-1. GHRP-2 promotes the formation of lean body mass even in harsh settings by inhibiting degradation and increasing deposition.
❷ Appetite Stimulation
GHRP-2 has been demonstrated to increase meal intake. Though it may not appear to be an urgent matter, appetite stimulation in the context of chronic disease is an important aspect of total health care. The ability to boost hunger simply and consistently could help doctors manage chronically unwell patients and improve long-term outcomes.
❸ Strengthens the Immune System
GHRP-2 has been proven to stimulate the thymus, an organ important for protecting immune system cells. The thymus, in particular, aids in the maturation of T lymphocytes. T cells are essential for adaptive immunity and fighting off complicated infections. The thymus’ function declines with age, resulting in a variety of age-related dysfunctions ranging from poor tissue repair to loss of immunity, and hence an inability to fight infections, protect against cancer, and maintain normal tissue function. The thymus has been demonstrated to be rejuvenated by GHRP-2, increasing the amount and diversity of T-cells produced. This results in increased immunity.[4][5]
❹ Protect the heart
GHRP-2 and its analogues (GHRP-1 and GHRP-6) have been shown in fetal heart cell culture lines to help protect heart cells by lowering apoptosis, or programmed cell death. This is especially important after a cardiac attack, when heart cells are more prone to apoptosis due to decreased blood and hence nutrition availability. According to research employing an equivalent of GHRP-2 called Hexarelin, these peptides may have a particular receptor. Identifying new receptors in any tissue not only opens up new avenues for medication development, but it also expands our understanding of human physiology and how to avoid malfunctioning in the first place.
❺ Enhances Sleep Quality
GHRP-2 has been demonstrated to enhance the duration of stages 3 and 4 of the sleep cycle by around 50% each, increase REM sleep by about 20%, and reduce the amount that an individual deviates from “normal sleep” by up to a third. Overall, better sleep led to better cognitive function, blood pressure, healing, and energy levels. These findings, while applicable to all adults, are especially noteworthy in the elderly, since the effects of aging have a negative impact on sleep quality. GHRP-2 could help researchers better understand how to fine-tune sleep to increase quality and possibly even let people enjoy all the advantages of a full night’s sleep in a fraction of the time.
❻ Influence Pain Perception
GHRP-2 was initially considered that decreased pain in animal models of osteoarthritis was due to GHRP-2 increasing growth hormone levels and hastening repair in injured tissues. However, astute scientists noticed that pain relief came before healing by a significant margin, implying that GHRP-2 may have direct effects on pain perception. As it turns out, GHRP-2 acts on opioid receptors.
There are four opioid receptors that have been identified. Most opioid pain relievers do not distinguish between them. This is troublesome because some receptors govern pain, while others influence wakefulness and breathing, and yet others influence addiction. GHRP-2 is a selective opioid receptor agonist that binds primarily to the receptors involved in pain alleviation, sedation, and addiction. This discovery suggests that it may be possible to create selective opioid agonists and so limit or prevent completely undesired consequences such as respiratory depression and addiction.
What is Side effects of GHRP-2(Growth Hormone Releasing Peptide-2)?
The side effects of GHRP-2 should not be severe if occurring at all for most individuals if the hormone is used responsibly. If the hormone is taken appropriately, the adverse effects of GHRP-2 should be minor, if at all. However, side effects of GHRP-2 are possible, but they are far milder than those of many other hormones. Estrogenic: Estrogenic side effects of GHRP-2 should not exist because the peptide does not produce aromatization. However, gynecomastia in sensitive individuals, particularly those with preexisting gynecomastia, is conceivable. In sensitive men, high dosages of GHRP-2 may considerably elevate prolactin, resulting in prolactin-based gynecomastia.[6][7] Hepatotoxicity: GHRP-2 is not harmful to the liver and will not cause liver damage.
Growth Hormone Releasing Peptide: GHRP-2 Vs. GHRP-6
Growth Hormone Releasing Peptide-6(GHRP-6) is a synthetic hexapeptide that promotes the pituitary gland’s secretion of growth hormones. GHRP-6’s principal function, like GHRP 2, is to stimulate the release of growth hormone in the body.
GHRP-2 stimulates the production of more growth hormones, whereas GHRP-6 stimulates the release of fewer growth hormones. This is the primary distinction between GHRP-2 and GHRP-6. Another distinction between GHRP-2 and GHRP-6 is that GHRP-2 has a shorter half-life whereas GHRP-6 has a longer half-life.
Furthermore, the efficacy of GHRP-2 and GHRP-6 differs significantly. GHRP-2 has a higher potency than GHRP 6. Furthermore, GHRP-6 significantly increases appetite and hunger. In this sense, GHRP-2 has a lesser reaction.[8][9]
The infographic below provides more information about the distinction between GHRP-2 and GHRP-6:
Growth Hormone Releasing Peptide: GHRP-2 Vs. GHRP-6 | ||
Items | GHRP-2 | GHRP-6 |
Definition | GHRP-2 is a synthetic peptide that acts directly on pituitary somatotrophs to stimulate growth hormone release. | GHRP-6 is a also a synthetic hexapeptide that stimulate the pituitary gland to release growth hormone. |
Half-life | Has a shorter half-time | Has a comparatively longer half-life |
Potency | More potent | Less potent |
Release of growth hormone | Release more quantities of growth hormone comparatively | Release low quantities of growth hormones |
Appetite | Does not build appetide substantially | Builds hunger and appetide substantially |
Peptides | Contains 2 peptides | Contains 6 peptides |
GHRP-2 and GHRP-6 are two growth hormone-releasing peptides. They are utilized in professional bodybuilding. Aside from that, both hormones have distinct tasks. GHRP-2 has a higher potency than GHRP-6. The main distinction between GHRP-2 and GHRP-6 is the amount of growth hormone released. GHRP-2 stimulates growth hormone production more than GHRP-6. Furthermore, once injected, the GHRP-2 peak occurs within 15 to 60 minutes. As a result, it has a shorter half-life than GHRP-6. Significantly, GHRP 6 improves nitrogen absorption in the body and facilitates protein creation.[10][11]
Where to buy Growth Hormone Releasing Peptide-2 (GHRP-2)?
GHRP-2 is an abbreviation for Growth Hormone Releasing Peptide 2, which is essentially a hgH secretagogue that acts on the hypothalamus and pituitary gland to produce growth hormone while also having a small stimulatory effect on Prolactin, ACTH, and Cortisol levels. GHRP-2 is a real hGH secretagogue, which means it stimulates the body’s own hGH secretion. In research, human growth hormone has been proven to improve lean body mass and minimize adiposity (fat). GHRP2 has been shown to be highly effective at stimulating GH production in research test subjects.
For now, there are many people find the growth hormone Releasing Peptide 2(GHRP-2) and ready to inject it to improve muscle structure. Of course, there are also some researchers who interested in studying GHRP-2 may be also curious about where to buy this peptide GHRP-2 online.
It is not difficult to buy GHRP-2 online these days. While GHRP-2 is available online from a variety of vendors, it is important to purchase only research-grade GHRP-2 to ensure safe and worthwhile experimentation.Having tested multiple vendors, our preferred GHRP-2 source is Polypeptide.Ltd. Growth Hormone Releasing Peptide 2(GHRP-2) for sale at Polypeptide.Ltd belong to research-grade, they has reasonable prices with decent shipping times.
But we need to notice: it is important to discuss the potential risks and benefits of GHRP-2 use with a healthcare provider and to weigh the costs and benefits of treatment before making a decision. With more research and study, GHRP-2 could become an even more promising treatment for people with more disease.[12]
Manufacturers/Factory
Growth Hormone Releasing Peptide 2(GHRP-2) from Polypeptide.ltd is a synthetic hexapeptide Growth Hormone Releasing Peptide (GHRP) that acts on the brain and pituitary gland to produce growth hormone while also having a minor stimulatory effect on Prolactin, ACTH, and Cortisol levels. GHRP-2 is a real hGH secretagogue, which means it stimulates the body’s own hGH secretion. In research, human growth hormone has been proven to improve lean body mass and minimize adiposity (fat). GHRP-2 has been shown to be highly effective at stimulating GH production in research test subjects.
As the best GHRP-2 peptide manufacturer, Polypeptide.ltd is not only supply the peptide Growth Hormone Releasing Peptide 2(GHRP-2) in powder form but provide the customized standard easy use vial form. You can buy the best price GHRP-2 powder and best quality peptide from this professional peptide manufacturer.
Coa & MS
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1)Competitive Factory Price-Factory direct sales, No middlemen make a difference.
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1)Visit professional GHRP-2 supplier Polypeptide.ltd, choose the GHRP-2 you want to buy.
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3)The customer service will reply you in 12 hours once received your message, then talk in details about buy Growth Hormone Releasing Peptide 2(GHRP-2).
Does Polypeptide.ltd Support The Free Sample Of GHRP-2 Powder?
It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for sample.
Can I Appoint The GHRP-2 Colour When Buy GHRP-2?
YES! Polypeptide.ltd as peptide manufacturer, provide colour customization of GHRP-2, easy to help you to build your GHRP-2 peptide brand.
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YES! As one of the best Growth Hormone Releasing Peptide 2(GHRP-2) manufacturer, Polypeptide.ltd not only provide the standard specification of GHRP-2 in 5mg, 10mg, but support standard customization. Provide the best support to build your own GHRP-2 brand.
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YES! Our factory produce high quality GHRP-2 powder in term and keep GHRP-2 powder in stock. You can buy high quality GHRP-2 powder in bulk. During promotion sale, you can buy GHRP-2 peptide by lower price. You can keep touch with our customer manager and they will update the latest bulk GHRP-2 price for you in time.
FAQ
What is Peptide GHRP-2 used for?
GHRP-2 is utilized to build muscle, lose fat, and improve flexibility and joint health. GHRP-2 also promotes improved injury and exercise recovery. GHRP-2 also improves sleep, increases anti-aging benefits, and improves general health and fitness. Higher growth hormone levels also result in increased IGF-1 production in the body, which promotes lean body composition, stimulates muscular tissue growth, and lowers body fat. When administered long term, GHRP-2 generates significant increases in strength and endurance. This peptide has the potential to significantly increase athletic performance, physical capacity, and aging-related decline.
GHRP-2 is widely considered as one of the most effective growth hormone releasing peptides in terms of both athletic performance and anti-aging properties. It causes significant increases in growth hormone output while avoiding the severe hungry side effects associated with GHRP-6. This could result in large gains in lean body composition.
How to store Growth Hormone Releasing Peptide 2(GHRP-2)?
Because GHRP 2 is a lyophilized powder, the first step is to reconstitute it. If you’re not going to use it right away when reconstitution, you should carefully keep it. It is recommended that peptides be stored in a cool, dark area after reconstitution. Another approach is to keep them chilled. The ideal temperature is roughly 4 degrees Celsius (39 degrees Fahrenheit). Keep in mind that if you haven’t reconstituted the peptide, you can usually store it for a longer period of time. However, at this stage, it is recommended that it be stored at a temperature of -20 degrees Celsius or -4 degrees Fahrenheit.
Is it safe to inject GHRP-2?
GHRP-6 injection is a tiny molecular weight peptide that is effective when supplied orally, stable, and less expensive than others. Our finding that GHRP-6 intravenous delivery was safe in a dose-escalation clinical trial in healthy human volunteers is extremely significant.
What is safe dosage of GHRP-2?
It is vital to keep a few things in mind while calculating your own GHRP-2 dose. The first thing to mention is that GHRP-2 is often taken one to three times per day. If you want to increase your strength, many people use a greater amount of 300mcg, or around 0.3mg per dose, and take it three times a day. The most commonly used dosage protocol contains the smallest amount at 150mcg or 0.15mg per dose. If you’re not looking to use this peptide for strength gains but rather for anti-aging benefits, the lesser dose will suffice. It is best practice to avoid eating for at least one hour before using GHRP-2.
What is the best time to inject GHRP-2?
They are best taken 30 minutes before or after breakfast and before going to bed to enhance the body’s natural cycle of growth hormone production during REM sleep. They are available in injectable and sublingual versions to fit your unique requirements.
How long does GHRP-2 take to work for bodybuilding?
GHRP-2 treatment elevated plasma GH concentrations considerably throughout the experiment. Plasma GH concentrations peaked in 20 minutes and reverted to baseline between 120 and 150 minutes later.
GHRP-2 is a Growth Hormone Releasing Peptide that also functions as an appetite suppressant, resulting in greater weight loss:GHRP-2 lowers abdominal fat through a process known as lipolysis for bodybuilding.
Only GnRH pulses in combination with GHRP-2 + TRH infusion significantly elevated testosterone from day 2 (highest rise of + 312%) to day 5 and serum E2 by more than 80% from day 1 to day 3 (all P = 0.05).
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GHRP-2 Peptide dosage calculator
Referenced Citations
[1] Bisi G, Podio V, Valetto MR, et al. Cardiac effects of hexarelin in hypopituitary adults. Eur J Pharmacol. 1999;381(1):31–38.
[2] Demers A, McNicoll N, Febbraio M, et al. Identification of the growth hormone-releasing peptide binding site in CD36: a photoaffinity cross-linking study. Biochem J. 2004;382(pt 2):417–424.
[3] Braunwald E. Clinical efforts to reduce myocardial infarct size – the next step. J Cardiovasc Pharmacol Ther. 2011;16(3–4):349–353.
[4] Rossoni G, De Gennaro Colonna V, Bernareggi M, Polvani GL, Muller EE, Berti F. Protectant activity of hexarelin or growth hormone against postischemic ventricular dysfunction in hearts from aged rats. J Cardiovasc Pharmacol. 1998;32(2):260–265.
[5] Roh SG, He ML, Matsunaga N, Hidaka S, Hidari H. Mechanisms of action of growth hormone-releasing peptide-2 in bovine pituitary cells. J Anim Sci. 1997 Oct;75(10):2744-8. doi: 10.2527/1997.75102744x. PMID: 9331879.
[6] Furuta S, Shimada O, Doi N, Ukai K, Nakagawa T, Watanabe J, Imaizumi M. General pharmacology of KP-102 (GHRP-2), a potent growth hormone-releasing peptide. Arzneimittelforschung. 2004;54(12):868-80. doi: 10.1055/s-0031-1297042. PMID: 15646371.
[7] Iwase M, Kanazawa H, Kato Y, et al. Growth hormone-releasing peptide can improve left ventricular dysfunction and attenuate dilation in dilated cardiomyopathic hamsters. Cardiovasc Res. 2004;61(1):30–38.
[8] Xu X, Ding F, Pang J, et al. Chronic administration of hexarelin attenuates cardiac fibrosis in the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol. 2012;303(6):H703-H711.
[9] Ma Y, Zhang L, Launikonis BS, Chen C. Growth Hormone secretagogues preserve the electrophysiological properties of mouse cardiomyocytes isolated from in vitro ischemia/reperfusion heart. Endocrinology. 2012;153(11):5480–5490.
[10] Mao Y, Tokudome T, Kishimoto I, et al. Hexarelin treatment in male ghrelin knockout mice after myocardial infarction. Endocrinology. 2013;154(10):3847–3854.
[11] Granado M, Priego T, Martin AI, Villanua MA, Lopez-Calderon A. Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats. Am J Physiol Endocrinol Metab. 2005;288(3):E486-E492.
[12] Subiros N, Perez-Saad HM, Berlanga JA, et al. Assessment of dose-effect and therapeutic time window in preclinical studies of rhEGF and GHRP-6 coadministration for stroke therapy. Neurol Res. 2015;38(3):187–195.
Scientific Journal paper Author:
- T Phung
Laboratory of Animal Production, Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, 2–11 Nishi, Inada-cho, Obihiro 080-8555, Japan
- N Matsunaga
Laboratory of Animal Production, Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, 2–11 Nishi, Inada-cho, Obihiro 080-8555, Japan
- Xiaoxi Yan
Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, 210095 Nanjing, China
- Ailian Lin
Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, 210095 Nanjing, China
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.
Author of this article:
Dr. Jean Zeng graduated from king's college london Faculty of Life Sciences & Medicine.
Scientific Journal paper Author:
Stephen C. Bain
Diabetes Research Group, Swansea University Medical School, Swansea, SA2 8PP, UK
Department of Diabetes and Endocrinology, Singleton Hospital, Swansea Bay University Health Board, Swansea, SA2 8QA, UK
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.
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