PT-141

PT-141 Molecular Structure

Authoritative source：PubChem

What is Peptide PT–141(Bremelanotide)?

Peptide PT-141, also known as bremonotide, is a novel new medication that has attracted medical and scientific interest for its ability to treat sexual dysfunction in both men and women. This peptide has been extensively researched for its capacity to boost libido and excitement, making it a promising treatment option for patients suffering from low libido or other forms of sexual dysfunction. It is currently FDA-approved for the treatment of premenopausal women with acquired, global sexual hyposexuality condition (HSDD).[1]

So, can we conclude that PT-141 is the most effective peptide for sexual health? Is it equally safe and effective for men and women? Continue reading to find the most recent information on how PT-141 works, its benefits for men and women, and potential hazards.

How Does PT–141(Bremelanotide) Work?

PT-141(Bremelanotide) is a peptide hormone that has become popular for its ability to rapidly increase sexual desire and arousal in both men and women. It is a melanocortin-based drug that acts by activating certain brain receptors to produce different types of hormones that directly affect libido.

PT-141 does not work like standard erectile dysfunction medications like Viagra; instead, it affects brain regions related with sexual excitement.The active element in PT-141 raises hormone levels such as norepinephrine, dopamine, and serotonin. These hormones boost blood flow to the genitals, resulting in increased physical pleasure during intercourse. It also increases the sensitivity of nerve endings, which amplifies messages conveyed from the brain to the body.

With the onset of middle age, erectile dysfunction, vaginal dryness, decreased libido, and other poor sexual performance issues become a problem. PT-141 intends to assist anyone who is experiencing a decline in their sexual life.[5]

What are the Benefits of Peptide PT–141(Bremelanotide)?

Extensive clinical research has shown that PT-141 can help with a range of diseases, including erectile dysfunction, HSDD in premenopausal women, and even weight reduction. We have prepared the following benefits of the peptide PT141 based on research data:

❶ PT-141 and Male Erectile Dysfunction

Researchers have shown that PT-141 has therapeutic efficacy in male individuals with erectile dysfunction, even when other therapies have failed.[11]

In a 2004 trial, researchers gave PT-141 injections to both healthy men and men who had erectile dysfunction but were not responding to Viagra. In the healthy males, 1mg doses were adequate to cause erection, whereas 4mg or 6mg doses produced erection in the ED Viagra-non-responder group. All patients tolerated the medication well, leading the researchers to conclude that the peptide is a promising treatment for male sexual dysfunction.

Intranasal delivery of PT-141 has also been proven to provide beneficial results in males with ED, this time in Viagra-responsive patients. A double-blind, placebo-controlled trial discovered that nasally delivered PT-141 at doses greater than 7mg elicited an erectile response as soon as 30 minutes after treatment, with no known safety issues.[12]

Similarly, a randomized, placebo-controlled research looked at the effects of intranasal PT-141 delivery in Viagra-non-responsive ED patients. Prior to intercourse, the PT-141 group was instructed to self-administer a 10mg PT-141 dose by nasal spray. In the end, males receiving PT-141 reported “significantly greater intercourse satisfaction” than those in the placebo group.[9]

❷ PT-141 and Female HSDD

According to experts, roughly 10% of women in the United States have low libido or none at all. This lack of sex drive in women, known as hypoactive sexual desire disorder (HSDD), has been related to hormonal abnormalities and aberrant levels of dopamine and serotonin. As a possible treatment for HSDD, PT-141, a melanocortin known to act on the excitatory circuit implicated in female sexual response, was found.

Researchers assessed the safety and efficacy of PT-141 therapy in premenopausal women with HSDD in two identical 24-week phase 3 trials. The PT-141 patient group was told to self-administer a dosage of 1.75mg subcutaneously as needed. PT-141 therapy dramatically enhanced sexual desire and reduced HSDD-related distress in both studies, with very minor side effects recorded.

The FDA approved injectable PT-141 as a therapy for HSDD in premenopausal women after the clinical research program (RECONNECT) was completed.[7]

❸ PT-141 and Better Mood

As previously stated, PT-141 increases emotions of sexual desire, arousal, and satisfaction associated with sexual engagement.

Researchers believe that these effects are achieved by activating the MC4R in the hypothalamus, resulting in an increase in dopamine. Because dopamine is linked to feelings of motivation and reward, researchers predict that PT-141 treatment could improve patients’ general mood, including increased optimism bias.[3]

❹ PT-141 and Weight Loss

The MC4R has been related to hunger management in addition to its involvement in modulating sexual desire. When activated, the receptor can enhance satiety or the sensation of being full. Two phase one clinical trials were conducted to assess the safety and efficacy of PT-141 therapy in obese female participants, with the goal of determining whether the peptide could reduce calorie consumption and body weight.[4]

During the 16-day trial period, individuals received either once-daily, twice-daily, or thrice-daily PT-141 subcutaneous injectable treatment or placebo. After the two studies were completed, 90% of the women in the thrice-daily group had a greater reduction in body weight against placebo, and the twice-daily group had a “significantly greater reduction” in body weight compared to placebo. According to the researchers, PT-141′s action at the MC4R makes it a promising therapeutic agent in obese people.

How Does PT-141 Enhance Libido and Sexual Function?

PT-141, commonly known as bremelanotide, is an injectable chemical that can be used to increase libido. It has been demonstrated that increasing desire increases physical arousal and genital circulation, hence increasing the fullness and function of erectile and other genital tissue in both men and women. There is a substantial link between sexual excitement and sexual performance ability. This medicine addresses both. Unlike conventional oral drugs such as Viagra, Cialis, or Levitra, PT-141 stimulates arousal by acting directly on the neurological system. When appropriately dosed, it eliminates the risk of priapism (a prolonged and often unpleasant erection), headache, and congestion. Furthermore, PT-141 may enhance dopamine release. Dopamine is commonly considered of as a pleasure molecule, but it has lately been linked to motivational salience. To put it another way, the urge to perform an act based on the perceived level of satisfaction or consequence.[8]

What are the difference between Bremelanotide PT-141 and Melanotan II (MT2)?

As you may have noticed, PT-141 and Melanotan II(MT2) act and influence the body in very similar ways. Because bremelanotide is the primary component of both synthetically generated peptides. As a result, by affecting the central nervous system rather than the vascular system, both substances boost libido, sexual desire, and sexual function.[6]

Both substances accomplish this by raising dopamine production and attaching to melanocortin receptors in the brain, which aids in the rise of sexual arousal and desire, resulting in greater sexual function in both men and women.

Melanotan(MT2), unlike PT-141, stimulates sexual desire by stimulating the MC-3 and MC-4 receptors in the brain, resulting in increased sexual function. Melanotan II is closely related to PT-141 and contains similar components.

Based on what we know so far about PT-141 and Melanotan II, there is little doubt that they are potent peptides with great sexual advantages. Whether you’re having difficulty getting physically aroused, have a low sex drive or libido, or don’t enjoy sex, PT-141 and MT-II may be able to assist. However, before using either of these medications, you must obtain medical counsel and assistance from a healthcare expert.

What are the Side Effects of PT-141(Bremelanotide)?

As with any medication, PT-141 can cause side effects in some people. The most commonly reported side effects of PT-141 use are:

PT 141(Bremelanotide) may cause serious side effects：

▪ Severe or ongoing nausea;

▪ Slow heartbeats;

▪ High blood pressure–severe headache, blurred vision, pounding in your neck or ears.

PT 141(Bremelanotide) has some common side effects:

▪ Nausea, vomiting;

▪ Flushing (sudden warmth, redness, or tingly feeling);

▪ Cough, stuffy nose;

▪ Headache, tiredness, dizziness;

▪ Pain, bruising, redness, itching, bleeding, numbness, or tingling where an injection was given.

Even though PT-141 is generally well-tolerated, it is important to remember that how often and how bad these side effects are can vary from person to person. People may sometimes have more serious side effects, such as vomiting, blurry vision, and dizziness. It’s important to talk to a doctor immediately if you notice any of them.

Because PT-141 is a relatively new treatment option, there is currently limited data available on the long-term effects of PT-141 use. Before starting treatment, it is important to talk to a healthcare provider about the possible risks and benefits of using PT-141. It is also important to take medicine exactly as your doctor tells you to and immediately tell your doctor if you have any side effects.

Where to buy Peptide PT-141(Bremelanotide)?

PT-141 is a man-made peptide that was originally developed as a sunless tanning agent, but it has shown a lot of promise as a possible treatment for sexual dysfunction. Especially, it has great helpful on the treatment of erectile dysfunction or impotence in men and HSDD (hypoactive sexual desire disorder) in women.

For now, there are many people find this peptide and ready to inject it to improve the life. Of course, there are also some researchers who interested in studying PT-141 may be also curious about where to buy this peptide PT 141 online.[2]

It is not difficult to buy PT-141 online these days. While PT-141 is available online from a variety of vendors, it is important to purchase only research-grade PT-141 to ensure safe and worthwhile experimentation.Having tested multiple vendors, our preferred PT-141 source is Polypeptide.Ltd. They consistently supply research-grade PT-141 at reasonable prices with decent shipping times.

But we need to notice: it is important to discuss the potential risks and benefits of PT-141 use with a healthcare provider and to weigh the costs and benefits of treatment before making a decision. With more research and study, PT-141 could become an even more promising treatment for people with more disease.

How to Store Peptide PT-141 from Polypeptide Ltd.?

The PT-141 injectable (Polypeptide Ltd.) does not require refrigeration and can be stored at temperatures below 77°F (25°C). Even when not refrigerated, they have a shelf life of roughly 12 months.

The injection should not be refrigerated or exposed to severe temperatures or direct sunlight, since this can cause the peptide to degrade. Because each pen is single-use, it can be discarded immediately after use.

Manually reconstituted peptides with bacteriostatic water (0.9% benzyl alcohol) must be refrigerated at 36°F to 46°F (2°C to 8°C) for up to 28 days.[10]

Polypeptide PT-141, also known as Bremelanotide, is a miraculous peptide and synthetic analogue of the naturally occurring peptide hormone a-MSH.PT-141 is a compound with all the sexual enhancement properties of Melatonan II, but without the increase in melanogenesis. It’s approved by the FDA for the treatment of low sexual desire in women but is also used by men to improve erectile function.Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido. Resultantly, PT-141 has been shown in studies to exhibit libido-enhancing effects by activating the melanocortin receptors MC1R and MC4R, but not skin tanning. Melanotan 1 and Melanotan 2 have been researched for their use in protecting against the harmful effects of ultraviolet radiation from sunlight due to their melanogenesis-stimulating properties.

As the best PT-141 peptide manufacturer, Polypeptide.ltd is not only supply the peptide PT-141(Bremelanotide) in powder form but provide the customized standard easy use vial form. You can buy the best price PT 141 and best quality peptide from this professional peptide manufacturer.

Would you like to buy the best peptide from the best PT-141 suppliers in the market? You have come at the right place!  

Polypeptide.ltd as a peptide factory, is the best place where you can buy PT-141(Bremelanotide) in compeptitive price, from small to bulk quantity. Click and make a contact, you will get all the details. Before buy PT 141, you may curious:

What Are The Advantages If Buy PT-141(Bremelanotide) From Polypeptide.ltd?

1)Competitive Factory Price-Factory direct sales, No middlemen make a difference.

2)Customization Service-Product specifications can be customized to create your own peptide brand.

3)Quality Guarantee-Professional lab reports along with shipment.

4)Fast Shipping-Professional logistics customization solutions, on-time delivery.

5)Easy Payment-Payment methods that are diverse.

6)365/24/7 Service-High quality pre-sales and after-sales service, followed by product and order details consultation.

How To Get The Quick Price Of PT-141 Online?

1)Visit professional PT-141 supplier Polypeptide.ltd, choose the PT-141 you want to buy.

2)Leave your contact and message on polypeptide.ltd website, then submit to polypeptide.ltd.

3)The customer service will reply you in 12 hours once received your message, then talk in details about buy PT-141.

Does Polypeptide.ltd Support The Free Sample Of PT-141 Powder?

It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for sample.

Can I Appoint The PT-141 Colour When Buy PT-141?

YES! Polypeptide.ltd as peptide manufacturer, provide colour customization of PT-141, easy to help you to build your bremelanotide peptide brand.

Can I Appoint The Products Standard When Buy PT-141 From Polypeptide.ltd?

YES! As one of the best PT141(Bremelanotide) manufacturer, Polypeptide.ltd not only provide the standard specification of PT-141 in 5mg, 10mg, but support standard customization. Provide the best support to build your own PT-141 brand.

Can I Buy PT-141 In Pure Powder Form From Polypeptide.ltd?

YES! PT-141 powder is the base that use for PT-141 lyophilized powder manufacture. Polypeptide.ltd provide PT-141 in both of pure powder form and semi-finished vial form.

Can I Buy Discount PT-141 Powder From Polypeptide.ltd?

YES! Our factory produce high quality PT-141 powder in term and keep PT-141 powder in stock. You can buy high quality PT-141 powder in bulk. During promotion sale, you can buy PT-141 peptide by lower price. You can keep touch with our customer manager and they will update the latest bulk PT-141 price for you in time

How to reconstitute Peptide PT-141?

Reconstituted injectable PT-141 should be done using bacteriostatic or sterile water. Drip bacteriostatic or sterile water down the side of the PT-141 vial to reconstitute it. Allow the solution to dissolve naturally.

Does PT-141 boost testosterone?

No. Current research investigations do not demonstrate that PT-141 has any effect in testosterone production.

Is it safe to use PT-141?

PT-141 is a peptide that has gained popularity due to its ability to give sexual rejuvenation benefits. However, many individuals are concerned about its safety for human use. While the FDA has not yet authorized PT-141, tests have shown that it is generally safe to use when taken as indicated.

In most investigations, the adverse effects of PT-141 were mild and easily tolerated. Headache, flushing of the cheeks, nausea, and dizziness are all common reported adverse effects.However, these effects usually go away once the person stops using PT-141 or takes a lesser dose. Additionally, some users may develop more serious side effects, such as chest pain or difficulty breathing as a result of an allergic response; if this occurs, it is critical to seek medical treatment immediately.

While PT-141 is not for everyone, it is crucial to seek your doctor’s consent before using it. Visit a male clinic to see if you are eligible for PT-141 or other erectile dysfunction therapies.

How long does PT-141 last?

The effects of PT-141 can be felt within 30 minutes of intake, with peak levels occurring roughly two hours later. The duration of its effect varies from person to person, but most users report feeling its effects for several hours after taking it.

However, there is no definitive answer as to how long the effects will continue because everyone reacts differently based on their specific physiology and metabolism. However, the effects normally wear off four to eight hours after dose.

Most patients take PT-141 when they are going to engage in sexual activity with their spouse. This could improve their sexual performance and wellbeing.

How to inject PT-141?

Subcutaneous injection of injectable PT 141 into the abdominal or thigh muscles is the most common method of administration. Before administering any injection, carefully read the manufacturer’s instructions. Before injecting the solution, use sterilized needles and syringes, and wipe the injection site with an alcohol swab. Injections should be given no more than three times each week, at least two hours apart.