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Semaglutide

Semaglutide

Other names:Ozempic; Rybelsus; NN9535; Wegovy

Many clinical trials proved that semaglutide powder is an effective product for weight loss, obesity and type 2 diabetes.Its GLP-1 receptor agonist action effectively reduces appetite, induces fullness, and slows gastric emptying, resulting in significant weight loss. The impressive results underscore semaglutide powder’s capacity to address multiple health concerns simultaneously. This powdered formulation holds promise in reshaping therapeutic approaches for individuals seeking integrated solutions for weight management and improved metabolic health.

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Referenced Citations

[1]Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group.”Once-Weekly Semaglutide in Adults with Overweight or Obesity.”N Engl J Med. 2021 Mar 18;384(11):989-1002. doi: 10.1056/NEJMoa2032183. Epub 2021 Feb 10.PMID: 33567185

[2]Rubino DM, Greenway FL, Khalid U, O’Neil PM, Rosenstock J, Sørrig R, Wadden TA, Wizert A, Garvey WT; STEP 8 Investigators.”Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial.”JAMA. 2022 Jan 11;327(2):138-150. doi: 10.1001/jama.2021.23619.PMID: 35015037

[3]Frías JP, Davies MJ, Rosenstock J, Pérez Manghi FC, Fernández Landó L, Bergman BK, Liu B, Cui X, Brown K; SURPASS-2 Investigators.”Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes.”N Engl J Med. 2021 Aug 5;385(6):503-515. doi: 10.1056/NEJMoa2107519. Epub 2021 Jun 25.PMID: 34170647

[4]Weghuber D, Barrett T, Barrientos-Pérez M, Gies I, Hesse D, Jeppesen OK, Kelly AS, Mastrandrea LD, Sørrig R, Arslanian S; STEP TEENS Investigators.”Once-Weekly Semaglutide in Adolescents with Obesity.”N Engl J Med. 2022 Dec 15;387(24):2245-2257. doi: 10.1056/NEJMoa2208601. Epub 2022 Nov 2.PMID: 36322838

[5]Smits MM, Van Raalte DH.”Safety of Semaglutide.”Front Endocrinol (Lausanne). 2021 Jul 7;12:645563. doi: 10.3389/fendo.2021.645563. eCollection 2021.PMID: 34305810

[6]Rubino D, Abrahamsson N, Davies M, Hesse D, Greenway FL, Jensen C, Lingvay I, Mosenzon O, Rosenstock J, Rubio MA, Rudofsky G, Tadayon S, Wadden TA, Dicker D; STEP 4 Investigators.”Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial.”JAMA. 2021 Apr 13;325(14):1414-1425. doi: 10.1001/jama.2021.3224.PMID: 33755728

[7]O’Neil PM, Birkenfeld AL, McGowan B, Mosenzon O, Pedersen SD, Wharton S, Carson CG, Jepsen CH, Kabisch M, Wilding JPH.”Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial.”Lancet. 2018 Aug 25;392(10148):637-649. doi: 10.1016/S0140-6736(18)31773-2. Epub 2018 Aug 16.PMID: 30122305

[8]Chao AM, Tronieri JS, Amaro A, Wadden TA.”Semaglutide for the treatment of obesity.”Trends Cardiovasc Med. 2023 Apr;33(3):159-166. doi: 10.1016/j.tcm.2021.12.008. Epub 2021 Dec 21.PMID: 34942372

[9]Singh G, Krauthamer M, Bjalme-Evans M.”Wegovy (semaglutide): a new weight loss drug for chronic weight management.”J Investig Med. 2022 Jan;70(1):5-13. doi: 10.1136/jim-2021-001952. Epub 2021 Oct 27.PMID: 34706925

[10]Wadden TA, Bailey TS, Billings LK, Davies M, Frias JP, Koroleva A, Lingvay I, O’Neil PM, Rubino DM, Skovgaard D, Wallenstein SOR, Garvey WT; STEP 3 Investigators.”Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial.”JAMA. 2021 Apr 13;325(14):1403-1413. doi: 10.1001/jama.2021.1831.PMID: 33625476

[11]Christou GA, Katsiki N, Blundell J, Fruhbeck G, Kiortsis DN.”Semaglutide as a promising antiobesity drug.”Obes Rev. 2019 Jun;20(6):805-815. doi: 10.1111/obr.12839. Epub 2019 Feb 15.PMID: 30768766

[12]Meier JJ.”Efficacy of Semaglutide in a Subcutaneous and an Oral Formulation.”Front Endocrinol (Lausanne). 2021 Jun 25;12:645617. doi: 10.3389/fendo.2021.645617. eCollection 2021.PMID: 34248838

[13]Garvey WT, Batterham RL, Bhatta M, Buscemi S, Christensen LN, Frias JP, Jódar E, Kandler K, Rigas G, Wadden TA, Wharton S; STEP 5 Study Group.”Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial.”Nat Med. 2022 Oct;28(10):2083-2091. doi: 10.1038/s41591-022-02026-4. Epub 2022 Oct 10.PMID: 36216945

[14]Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR, Jeppesen OK, Lingvay I, Mosenzon O, Pedersen SD, Tack CJ, Thomsen M, Vilsbøll T, Warren ML, Bain SC; PIONEER 6 Investigators.”Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.”N Engl J Med. 2019 Aug 29;381(9):841-851. doi: 10.1056/NEJMoa1901118. Epub 2019 Jun 11.PMID: 31185157

[15]Wilding JPH, Batterham RL, Davies M, Van Gaal LF, Kandler K, Konakli K, Lingvay I, McGowan BM, Oral TK, Rosenstock J, Wadden TA, Wharton S, Yokote K, Kushner RF; STEP 1 Study Group.”Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension.”Diabetes Obes Metab. 2022 Aug;24(8):1553-1564. doi: 10.1111/dom.14725. Epub 2022 May 19.PMID: 35441470

Author of this article:

Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.

Scientific Journal paper Author:

1.Jesse Richards

Department of Internal Medicine, University of Oklahoma School of Community Medicine, Tulsa, OK, USA

2.Coenraad Withaar MSc

University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands 

3.Peter Kurtzhals

Novo Nordisk A/S, Vandtaarnsvej 110-114, DK-2860, Søborg, Denmark

4.Satoshi Iwai

Department of Gastroenterology, Nara Medical University, Kashihara, Nara 634-8521, Japan

5.Dimitrios Patoulias

Outpatient Department of Cardiometabolic Medicine, Second Department of Cardiology, Aristotle University of Thessaloniki, General Hospital “Hippokration”, Thessaloniki, Greece

In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.

Author of this article:

Dr. Jean Zeng graduated from king's college london Faculty of Life Sciences & Medicine.

Scientific Journal paper Author:

Stephen C. Bain
Diabetes Research Group, Swansea University Medical School, Swansea, SA2 8PP, UK
Department of Diabetes and Endocrinology, Singleton Hospital, Swansea Bay University Health Board, Swansea, SA2 8QA, UK

In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.