Semax

Semax Structure

Image of Semax without the N-acetyl side chain

Authoritative source：PubChem

What Is Semax Peptide

Semax is a synthetic peptide drug. It was developed based on the molecular structure of the adrenocorticotropic hormone, which is produced by the pituitary gland. It was originally used in Russia for the prevention and treatment of circulatory disorders such as stroke. It has the ability to enhance cognition, protect brain cells, and ward off depression.[1][2]

N-Acetyl Semax (Na-semax and Na-semax-NH2) is a synthetic peptide valued for its neurogenic and neurorestorative properties. Research shows it improves memory and cognitive function and is effective against diseases of the optic nerve, stroke, and ischemic heart disease. It may also boost immune function.

In the U.S. and around the world, Semax is the basis for a number of drugs that are used in clinical practice for the treatment of CNS diseases (ischemic brain stroke, dys-circulatory encephalopathy, optic nerve atrophy, etc.) and to enhance adaptability under extreme conditions in healthy persons.

How Does Semax Works?

Semax increases brain-derived neurotrophic factor (BDNF) levels. BDNF is among the most active neurotrophins, which are chemicals that help to stimulate and control neurogenesis, the birth of new neurons in the brain.

BDNF has been shown to play a role in neuroplasticity, which allows nerve cells in the brain to compensate for injury and adapt to new situations or changes in the environment. Basically, BDNF helps to support the survival of existing neurons and encourages the growth, regeneration, and creation of new neurons and synapses.

Semax also helps reduce the breakdown of enkephalins. Enkephalins are mainly involved in decreasing pain, reducing inflammation, preventing cancer cell growth, and increasing immune cell activity. They also play a role in memory, learning, emotional behavior, and pain. Balanced enkephalins levels are needed to maintain normal brain function. These early findings have led some researchers to suggest that Semax may have some potential as a pain reliever, although much more research would be needed to confirm these preliminary cell-based findings.

Based on what Semax can do for brain function and health, its capabilities as a treatment option are continually being developed.

What are the benefits of Semax peptide?

Some of the benefits of Semax may include:

• Increased attention and short-term memory
• Improved Non-proliferative Diabetic Neuropathy
• Can help during recovery from Stroke/Hypoxia
• Improved Glaucoma Optic Neuropathy
• May act as an Analgesic (pain reliever) by inhibiting Enkephalin breakdown
• Can be helpful in the treatment of ADHD
• Nootropic (cognitive-enhancing) effects
• Neuroprotection: may help protect the brain from various types of stress and damage

1.Preventing or Reducing Brain and Nerve Damage

Semax has been shown to protect the body and brain from various types of oxidative damage/stress.[3][4]

In animal studies, Semax has been shown to prevent oxidative damage caused by the poisonous effects of lead exposure in the brain.

Semax has been shown to prevent the oxidative liver damage which occurs with chronic stress in lab animals.

Semax also prevents oxidative damage to the body after a stroke or heart attack [R]. Researchers have suggested that this improvement is in part a result of oxidative protection.

2.Improving Memory

Semax improved memory and attention in a Russian study of task performance in healthy men. Semax also decreased learning time in animal studies.[5][8]

Some researchers have suggested that the resistance to oxidative damage in the brain and improved brain circulation might explain the improved memory seen in these subjects.

3.Protecting the Cardiovascular System

Semax can be used in the treatment of ischemic stroke in patients. In rats, it is capable of protecting the heart from damage after a stroke or heart attack.

The drug partially prevents the growth of the heart caused by high blood pressure, thus potentially preventing heart failure development after a heart attack.

A major risk factor for stroke is chronically poor circulation in the brain, a condition medically known as cerebrovascular insufficiency. Patients with different stages of cerebrovascular insufficiency saw significant stabilization of disease progression and reduced risk of stroke when treated with Semax in one study (retrospective review). Researchers attributed the results in part to improved circulation.[6][7]

4.Counteracting Stress

Semax has been shown to decrease the negative physical and mental responses to stress in animal studies.

One negative physical response to chronic stress is the increased production of specific liver enzymes. Treatment with Semax was shown to prevent their increase in several animal studies.

Semax normalized behavioral changes associated with increased stress resulting from physical injury. Semax also normalized behavioral changes associated with increased stress due to developmental problems in animals.

5.Stimulating Neurogenesis

Semax increases the brain levels of a substance known as the brain-derived neurotrophic factor (BDNF).

BDNF is a major chemical factor that is essential for cognitive development, synaptic plasticity, and neuronal survival. Studies indicate that low levels of BDNF may also cause or worsen depression and anxiety. By increasing the level of BDNF, Semax could help alleviate anxiety and depression. Animal studies have also indicated that Semax normalizes behavior associated with increased stress and anxiety, possibly as a result of this mechanism.

In a study (randomized controlled trial) of patients recovering from the stroke, Semax improved restoration of nerve function in subjects relative to those that did not receive the same treatment. This improvement in nerve function may be a result of increased BDNF.[9][10]

6.Alleviating Pain

Semax prevents the breakdown of chemicals called enkephalins which regulate the response to pain. An increase in enkephalins may reduce the severity of perceived pain.

7.May Help ADHD Symptoms

Semax has a number of effects that may be helpful in the treatment of ADHD, including memory improvement and the increase of neurotransmitters which are often lower in patients with this condition.

Semax side effects and safety

Semax side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the patient had one of the issues listed below at some point while being on Semax. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of Semax. Despite this, it was listed as a side effect associated with Semax even though these associated side effects are very uncommon.

Side effects associated with Semax may include the following:

• Hair loss
• Discoloration of the nasal cavity
• Increase in blood sugar levels of diabetic patients

Differences and Similarities between Semax and Selank

Semax and Selank are two synthetic peptides that have distinct characteristics and applications.

Understanding the differences and similarities between these peptides is essential in determining their suitability for specific needs. Here are the key disparities and commonalities between Semax and Selank:

1. Mechanism of Action:

Semax: Semax is derived from adrenocorticotropic hormone (ACTH) and primarily acts as a cognitive enhancer. It promotes neuroprotection and improves cognitive function, memory, and attention.[11][12]

Semax is believed to modulate neurotransmitters and possesses anti-inflammatory properties, supporting brain health.

Selank: Selank, on the other hand, functions as an anxiolytic peptide. It exerts its effects by modulating the levels of neurotransmitters like serotonin and dopamine.

Selank reduces anxiety and stress levels, potentially promoting a calmer mind.

2. Primary Applications:

Semax: Semax is primarily used for cognitive enhancement, neuroprotection, and potential recovery after brain injury or stroke.

It is sought by individuals aiming to improve focus, motivation, and concentration during cognitive tasks and workouts.

The peptide’s potential anti-inflammatory properties make it of interest in various neurological conditions.

Selank: Selank’s primary application lies in its anxiolytic properties. It alleviates anxiety and stress, potentially benefiting individuals with anxiety disorders, performance anxiety, or pre-competition nerves.

Additionally, Selank has potential applications in the cosmetic industry due to its antioxidant effects, which may promote skin health.

3. Bodybuilding and Athletic Performance:

Semax: Semax has gained some attention in the bodybuilding community for its potential cognitive-enhancing effects. Improving mental clarity and reducing fatigue indirectly supports better training sessions and overall performance.

Selank: While Selank is not directly related to bodybuilding, its anxiolytic properties can indirectly benefit athletes.

By reducing anxiety and stress levels, Selank may help athletes manage pre-competition nerves and enhance their mental state, potentially positively impacting performance.[13][14]

4. Skin Health and Cosmetics:

Semax: Semax does not have direct applications in skincare or cosmetics.

Selank: Selank’s potential antioxidant properties make it of interest in the cosmetic industry.

It may be included in skincare formulations to support skin health, reduce oxidative stress, and minimize the appearance of fine lines and wrinkles.

Semax and Selank have distinct mechanisms of action and primary applications. Semax primarily focuses on cognitive enhancement and neuroprotection, while Selank is an anxiolytic.

However, both peptides share a commonality in potential antioxidant effects, with Selank finding potential applications in the cosmetic industry.

Considering these differences and similarities is important when determining the most appropriate peptide for individual needs.

Consulting with a healthcare professional is advisable before using any peptides or supplements.

Although Semax and Selank share the commonality of being synthetic peptides, they differ in their mechanisms of action and primary application areas.

Semax primarily targets cognitive enhancement and neuroprotection, while Selank focuses on reducing anxiety and potential cosmetic benefits.

In terms of similarities, both peptides are believed to have neuroprotective properties. While Semax aids brain injury recovery and stroke rehabilitation, Selank’s anxiolytic effects indirectly support overall brain health.

Both peptides exhibit potential antioxidant properties, with Selank finding application in cosmetic formulations.

Semax For Sale | Semax supplier

Semax is a peptide for patients with depression, decreased motivation, and with pathologies related to brain circulation dysfunction. Semax is best known for its neurogenic/neurorestorative and neuroprotective properties. It is a modified snippet of a hormone called adrenocorticotropic hormone (ACTH). Semax is the basis for a number of drugs that are used in clinical practice for the treatment of CNS diseases (ischemic brain stroke, dys-circulatory encephalopathy, optic nerve atrophy, etc.) and to enhance adaptability under extreme conditions in healthy persons. Researchers interested in experimenting with Semax want to ensure that they source this material from a reliable supplier. lf you’re looking to buying Semax online, it is essential to exercise caution and ensure that you obtain the peptide from a reputable and trustworthy manufacuturer. Polypeptide.Ltd is a highly reliable manufacturer that offers pharmaceutical grade peptides.[15]

Semax is a peptide best known for its nootropic, neuroprotective, and neurogenic/neurorestorative properties. It was developed based on the molecular structure of adrenocorticotropic hormone (ACTH). Preliminary research in cells, animal and small-scale human trials show potential benefits and uses of Semax.If you are looking for the professional and top peptide Semax manufacturer or factory, here is the right place where you are.

As the best Semax peptide manufacturer, Polypeptide.ltd is not only supply the peptide Semax in powder form but provide the customized standard easy use vial form.

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Obtaining them from reliable and reputable sources is important if you’re interested in purchasing Semax or Selank.

One such source is polypeptide.ltd, which offers the best semax wholesale prices. As with any peptide or supplement, it’s crucial to prioritize quality and safety, ensuring you are purchasing from a trusted supplier.

Polypeptide. ltd is known for providing high-quality peptides, including Semax and Selank. By sourcing from a reputable supplier, you can have confidence in the purity and authenticity of the products you receive.

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What is the drug Semax used for?

MOTS-c can supercharge your metabolism and increase your ability to exercise, Semax has been prescribed for anxiety, memory improvement, ischemic events, stroke, nerve regeneration, ADHD, opioid withdrawal and even chronic diseases such as ALS, Parkinson’s Disease, and Alzheimer’s. Semax has been known to be used as an Adderall alternative.

What does Semax peptide do?

Medical uses for Semax include treatment of stroke, transient ischemic attack, memory and cognitive disorders, peptic ulcers, optic nerve disease, and to boost the immune system.

What are the benefits of Semax for the brain?

Nootropic: Semax may enhance cognitive abilities, including learning, memory, attention/focus, and creativity. Neurorestorative (neuroplasticity): Semax may restore neuron structure and function to compensate for injury and adapt to new situations or changes in the environment.

Is Semax a stimulant?

It has been found to stimulate memory and attention in rodents and humans after intranasal application. Evidence from animal studies revealed that Semax can augment the effects of psychostimulants on central dopamine release and also stimulates central brain-derived neurotrophic factor (BDNF) synthesis.

Does Semax increase dopamine?

The synthetic peptide semax (a fragment of ACTH 4-7 Pro-Gly-Pro) enhances the release of extracell dopamine (DA) induced by D-amphetamine (5 mg/kg) in the striatum of Spraig-Dowley (SD) rats and increases the locomotor activity stimulated by D-amphetamine (2 mg/kg) in C57/BL6 mice.

Does Semax increase serotonin?

MOTS-c, a peptide originating from mitochondrial DNA, holds significant promise Intranasal semax also increased serotonin, but not dopamine, levels. However, it did potentiate the stimulatory effects of d-amphetamine (Eremin et al, 2005).