TB-500
Other names:Thymosin Beta 4, tb 500, tb500, tb-500, TMSB4X, Fx Peptide,Timbetasin, PTMB4, Tβ4, TB4X, TMSB4, X-linked, thymosin beta 4 X-linked
Polypeptide TB500, called Thymosin Beta-4 that is a recent discovered bioactive peptide, present in about all human and mammalian cells. This specifically be designed to promote various healing effects in the body(include injury recovery, flexibility, and inflammation etc), and gained significant attention in the medical and scientific communities. Nowadays, TB500 is sold online market as anti-aging and fitness aid, many fitness enthusiasts buy finished TB500 as recovery supplement product alongside a hormone therapy program to increase muscle mass.
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Properties
Description
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Properties
Sequence: | Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser |
Molecular Formula: | C212H350N56O78S |
Molecular Weight: | 4963g/mol |
PubChem CID: | 16132341 |
CAS Number: | 77591-33-4 |
Synonyms: | TB500; Thymosin beta4; Thymosin β4; Thymosin b4; Thymosin beta4 Acetate; Thymosin beta(4); Thymosin Beta 4; Thymosin beta-4; Thymosin beta4 (ox); Thymosin beta4 (human); Timbetasin; Tbeta4; |
Description
TB500 is the synthetic version of a natural compound called thymosin-beta-4. Thymosin is a hormone secreted from the thymus, its primary function is to stimulate the production of T cells, which are an important part of the immune system. Thymosin also assists in the development of B cells to plasma cells to produce antibodies. [1][3][5]The predominant form of thymosin, thymosin beta-4, is an actin, a cell building protein, the creates T-cells can boost the immune system to fight off disease. Research found TB500 play an important role in protection, regeneration and remodeling of injured and/or damaged tissues. The gene for Thymosin Beta-4 has also been found to be one of the first to be stimulated after an incident of injury. TB500 is not only effective in athletes for its injury recovery and performance-enhancing properties but also among those suffering from acute and chronic injuries or disease. It offers potential help for individuals looking to promote wound healing, decrease inflammation, and recover faster from surgeries or illnesses.
How does TB500 Peptide work
TB500 is versatile because of its molecular structure and light molecular weight. The TB500 peptide can travel long distances through tissue. It can circulate through the body and find the injured areas to help speed recovery. TB500 relies on upregulating cell-building proteins.[7][8][11][16]These proteins, like actin, help form contractile movements of muscle cells. The upregulation of actin lets TB500 increase cell growth and speeds healing. The upregulation increases the good inflammation that helps wounds heal fast. TB500 works by building new blood vessels and muscle tissue fibers while assisting in new cell migration and blood cell reproduction. TB500 also is a useful therapeutic drug as a result of the role it has been found to play in immunomodulatory processes. HIV, AIDS, influenza, colds, and other illnesses have all been treated using TB500. It has been used to partially cure inflammatory illnesses as well as heart attacks because of its cardio- and neuroprotective properties.
Possible Benefits/Result On TB500 Peptide
Peptide TB-500 has a range of benefits throughout the body(tendons, ligaments, muscles, skin, heart, and eyes).[12][15][13][11][14] It helps wounds heal quickly by promoting the growth of new blood vessels and muscle fibers, to upregulates cell building proteins. Peptide TB-500 works fast to reaches the injured area and begins to work when be injected, include:
- Tissue repair:TB500 can increase the rate at which new blood cells, blood vessels, and tissue fibers are formed, speeds healing and reduces scarring.
- Enthances Performance:TB500 can improve strength and endurance by promoting new blood and muscle cells.
- Cardiovascular health:Research shows TB500’s regenerative properties in various types of heart tissue, promoting overall cardiac health.
- Wound healing:Research shows TB500 can repair injured tissues, reduce downtime and get you back to your routine faster.
- Promote hair growth:Animal studies have shown that TB-500 can increase the rate of hair, making it potentially beneficial for those facing hair thinning or loss.
- Reduces inflammation:TB500 has a powerful anti-inflammatory properties, helps to decrease swelling in tissues and pain relief.
- Dry eye disorder treatment: Some clinical reported TB500 can use to treat eye discomfort and can gain “completely healed”.
- Insulin resistance:Study found that TB500 ameliorates hyperglycemia and improves insulin resistance in a mouse model of type 2 diabetes mellitus (T2DM), indicating that it may be an alternative insulin sensitizer.
- Tumor suppression:Researchers found TB500 may have a tumor suppressive function after conducted experiments on mice. It can suppress the proliferation of NSCLC cells by repressing Notch1 activation.
Side effects and safety on TB500 Peptide
TB-500 is a research chemical strictly intended for laboratory experimentation, still not have safe evaluation by United States Food and Drug Administration (FDA), so not be approved for human use. Only certified laboratory professionals and researchers who want to utilize it in in vitro investigations are allowed to purchase peptide TB-500 and make sure to buy TB500 peptide from legit top quality peptide manufacturer or supplier, can avoid to get scam and buy fake peptide.
So far, TB500 peptide have not been formally evaluated for safety in humans, but available data suggest their safety and tolerability when properly administered. Usually the adverse side effects of Tb500 is transient, and mild, these include:
- Fatigue
- Headache
- Dizziness
- Nausea
- Feverish
- Blurry vision
- Face flushing
- Changes in heart rate
- Bruising at the site of injection
- Changes in blood pressure
- Changes in appetite
- Pain at the site of injection
The above adverse effects typically subside on their own and correspond with the use of low-grade peptide TB500, when order TB500 online from unauthorized peptide suppliers, may be mislabeled or contain harmful contaminants, better to order from top reputable TB500 peptide factory or manufacturer.[9][10]
TB-500 vs BPC-157, what‘s the difference?
TB-500 and BPC-157 are both synthetic peptides, work similar in their mode of action. BPC-157 mediates upregulation of growth hormones, modulates Nitric Oxide synthesis, enhances blood vessel production, and modifies collagen production as well as bone proteins. TB-500 principally associates with actin, promotes cellular migration and regeneration, and blocks inflammatory chemokines and cytokines.This two peptide both are useful in wound healing and tissue formation, to exert powerful healing effects on injured muscle, joint, bone, and connective tissue.
However, the clearest differences between TB-500 and BPC-157 at their origins and chemical structures, another key difference is administration and which types of body tissue they most greatly affect.
TB-500 is often administered once or twice a week, with total weekly dosages ranging between 10 and 20mg. In contrast, BPC-157 is given daily doses ranging from 250mcg (0.25mg) to 1000mcg (1mg). As a result, weekly dosages range from 1.75 mg to 7 mg, which is much less than the equivalent.
TB500 For Sale | TB500 supplier
If you’re hoping to buy TB-500 online, will find a variety of vendors offering this peptide for sale online, usually sold the name”thymosin beta-4″ as research chemicals. And, it often have a label indicating that they are not to be used for human consumption.[1][2][6]
However, there are many bodybuilder find this peptide and ready to inject it to promote muscle repair. Of course, there are also some researchers who interested in studying TB500 may be also curious about where to buy this peptide TB500 online. It’s essential to exercise caution when you guys want to buy top quality peptide TB500, to ensure you obtain the peptide from a reputable and trustworthy manufacuturer. Polypeptide.Ltd is a highly reliable manufacturer, they consistently supply research-grade TB500 at reasonable prices with decent shipping times.
How to Store Peptide TB500 from Polypeptide Ltd.?
The TB500 injectable (Polypeptide Ltd.) does not require refrigeration and can be stored at temperatures below 77°F (25°C). Even when not refrigerated, they have a shelf life of roughly 12 months.
The injection should not be refrigerated or exposed to severe temperatures or direct sunlight, since this can cause the peptide to degrade. Because each pen is single-use, it can be discarded immediately after use.
Manually reconstituted peptides with bacteriostatic water (0.9% benzyl alcohol) must be refrigerated at 36°F to 46°F (2°C to 8°C) for up to 28 days.
Manufacturers/Factory
TB-500 is a synthesised peptide, essentially a short-chain version of the naturally occurring Thymosin Beta-4. Up to now, peptide TB-500 is one best healing compounds on the market for Injury Repair & Recovery Stack combine supplement, it stimulate wound healing via various biological mechanisms, can boost maximum recovery as well as healing together with adjustability, joint flexibility, and also protection against injury.
As the best TB500 peptide manufacturer, Polypeptide.ltd is not only supply the peptide TB500 in powder form but provide the customized standard easy use vial form.
You can buy the best price TB500 and best quality peptide from this professional peptide manufacturer.
Coa & MS
Where to buy?
Would you like to buy the best TB500 peptide from the best TB500 suppliers in the market? You have come at the right place!
Polypeptide.ltd as a peptide factory, is the best place where you can buy TB500 in compeptitive price, from small to bulk quantity. Click and make a contact, you will get all the details. Before buy TB500, you may curious:
What Are The Advantages If Buy TB500 From Polypeptide.ltd?
- Competitive Factory Price-Factory direct sales, No middlemen make a difference.
- Customization Service-Product specifications can be customized to create your own peptide brand.
- Quality Guarantee-Professional lab reports along with shipment.
- Fast Shipping-Professional logistics customization solutions, on-time delivery.
- Easy Payment-Payment methods that are diverse.
- 365/24/7 Service-High quality pre-sales and after-sales service, followed by product and order details consultation.
How To Get The Quick Price Of TB500 Online?
- Visit professional TB500 supplier Polypeptide.ltd, choose the TB500 you want to buy.
- Leave your contact and message on polypeptide.ltd website, then submit to polypeptide.ltd.
- The customer service will reply you in 12 hours once received your message, then talk in details about buy TB500.
Does Polypeptide.ltd Support The Free Sample Of TB500 Powder?
It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for sample.
Can I Appoint The TB500 Colour When Buy TB500?
YES! Polypeptide.ltd as peptide manufacturer, provide colour customization of TB500, easy to help you to build your TB500 peptide brand.
Can I Appoint The Products Standard When Buy TB500 From Polypeptide.ltd?
YES! As one of the best TB500 manufacturer, Polypeptide.ltd not only providethe standard specification of TB500 in 5mg, 10mg, but support standard customization. Provide the best support to build your own TB500 brand.
Can I Buy TB500 In Pure Powder Form From Polypeptide.ltd?
YES! TB500 powder is the base that use for TB500 lyophilized powder manufacture. Polypeptide.ltd provide TB500 in both of pure powder form and semi-finished vial form.
Can I Buy Discount TB500 Powder From Polypeptide.ltd?
YES! Our factory produce high quality TB500 powder in term and keep TB500powder in stock. You can buy high quality TB500 powder in bulk. During promotion sale, you can buy TB500 peptide by lower price. You can keep touch with our customer manager and they will update the latest bulk TB500 price for you in time.
FAQ
Does TB-500 increase muscle growth?
Yes, TB-500 have proved can increase lean muscle mass and reduce body fat, it’s a popular peptide among athletes and bodybuilders.
What is the dosage of TB-500
It depends on the purpose of TB-500 use, for acute injury and post-surgical healing, the dosing is typically higher than for chronic injury and anti-aging purposes. A healthcare professional will provide precise dosing instructions.
Is TB500 FDA approved?
TB-500 is a synthetic peptide for treatment to stimulate wound healing and tissue repair, still not be approved by FDA.
Where should TB500 be injected?
Any location on the body by injected subcutaneously or intramuscularly.
How often do you inject TB500?
The initial dosage of TB500 is 4~8mg per week for 4 to 6 weeks, followed by 2-6mg every 2 weeks to maintain its effects.
Does TB-500 cause weight gain?
No, still no data stated TB-500 cause weight gain.
Does TB-500 affect testosterone?
No, TB-500 does not act to boost testosterone production.
Can You Use BPC-157 & TB-500 Together?
Yes, we have have BPC-157 and TB500 blend(5mg+5mg).
Is TB500 safe for humans?
Yes, proper handling can promote muscle regeneration, angiogenesis and recovery.
How do take TB-500?
TB-500 is typically provided as lyophilized (freeze-dried) powder in vials. It is mixed with bacteriostatic or sterile water and injected subcutaneously or intramuscularly.
Is TB-500 a steroid?
No, TB-500 is not an anabolic-androgenic steroid.
Reviews
TB-500 Peptide dosage calculator
Referenced Citations
[1]Zhao X, Li N.”Thymosin β4 Alleviates Autoimmune Dacryoadenitis via Suppressing Th17 Cell Response”. Invest Ophthalmol Vis Sci. 2023 Aug 1;PMID: 37531112.
[2]Wang X, Zhou Y.”Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation”. 2023 Aug;Epub 2023 May 14.PMID: 37192732.
[3]Effects of thymosin beta 4-derived peptides on migration and invasion of ovarian cancer cells. | Yoon, HJ., et al. 2021. Genes Genomics. 43: 987-993. PMID: 34170491.
[4]Effects of Thymosin beta 4 on Myocardial Apoptosis in Burned Rats. | Wu, X., et al. 2022. J Healthc Eng. 2022: 2129629. PMID: 35281544.
[5]Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans SM, Chen J (Feb 2012). “Thymosin beta 4 is dispensable for murine cardiac development and function”. Circ Res. 110 (3): 456–64.PMC 3739283. PMID 22158707.Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD (Nov 2012). “Doping control analysis of TB-500, a synthetic version of an active region of thymosin β4, in equine urine and plasma by liquid chromatography-mass spectrometry”. Journal of Chromatography A. 1265: 57–69. PMID 23084823.
[6]Van Troys M, Dewitte D, Goethals M, Carlier MF, Vandekerckhove J, Ampe C (Jan 1996). “The actin binding site of thymosin beta 4 mapped by mutational analysis”. The EMBO Journal. 15 (2): 201–10. PMC 449934. PMID 8617195.
[7]Kleinman HK, Sosne G (2016). “Thymosin β4 Promotes Dermal Healing”. Thymosins. review. Vitamins and Hormones. Vol. 102. pp. 251–75. PMID 27450738.
[8]Safer D, Elzinga M, Nachmias VT (March 1991). “Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable”. J. Biol. Chem. 266 (7): 4029–32.PMID 1999398.
[9]Crockford D, Turjman N, Angel J (April 2010). “Thymosin beta4: structure, function, and biological properties supporting current and future clinical applications”. Annals of the New York Academy of Sciences. 1194 (1): 179–89. Bibcode:2010NYASA1194..179C. PMID 20536467. S2CID 29360082.
[10]Sosne G, Kleinman HK (August 2015). “Primary Mechanisms of Thymosin β4 Repair Activity in Dry Eye Disorders and Other Tissue Injuries”. Investigative Ophthalmology & Visual Science. 56 (9): 5110–7.PMID 26241398.
[11]Hypoxia-inducible transcription factor (HIF)-1 alpha stabilization by actin-sequestering protein, thymosin beta-4 (TB4) in Hela cervical tumor cells. Oh JM, Ryoo IJ, Yang Y, Kim HS, Yang KH, Moon EY. Cancer Lett. 264, 29-35, (2008). PMID: 18272284.
[12]Xing Yuan, Ye Yumeng, Zuo Hongyan, Li Yang. Progress on the Function and Application of Thymosin β4. Frontiers in Endocrinology. VOLUME 12 2021.
[13]Kleinman HK, Sosne G (2016). Thymosin β4 Promotes Dermal Healing. review. Vitamins and Hormones. 102. pp. 251–75.
[14]Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012 Jan;12(1):37-51. Epub 2011 Nov 10. PMID: 22074294.
[15]Goldstein AL, Kleinman HK. Advances in the basic and clinical applications of thymosin β4. Expert Opin Biol Ther. 2015;15 Suppl 1:S139-45. Epub 2015 Jun 22. PMID: 26096726.
[16]Maar K, Hetenyi R, Maar S, Faskerti G, Hanna D, Lippai B, Takatsy A, Bock-Marquette I. Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State-New Directions in Anti-Aging Regenerative Therapies. Cells. 2021 May 28; PMCID: PMC8228050.
Author of this article:
Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.
Scientific Journal paper Author:
Racing Laboratory, The Hong Kong Jockey Club, Sha Tin Racecourse, Sha Tin, N.T., Hong Kong, China.
Department of Biochemistry and Medical Chemistry, University of Pecs, Medical School, Pecs H-7624, Hungary.
Department of Ophthalmology, Visual & Anatomical Sciences, Kresge Eye Institute, Wayne State University School of Medicine, 4717 St. Antoine, Detroit, MI 48201, USA.
School of Life Sciences, Division of Physiology, Pharmacology & Neuroscience, University of Nottingham Medical School, Queens Medical Centre, Nottingham NG7 2UH, United Kingdom.
Bozok University School of Medicine, Department of Pathology, Adnan Menderes Bulvarı, No: 44, 66200, Yozgat, Turkey.
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.
Author of this article:
Dr. Jean Zeng graduated from king's college london Faculty of Life Sciences & Medicine.
Scientific Journal paper Author:
Stephen C. Bain
Diabetes Research Group, Swansea University Medical School, Swansea, SA2 8PP, UK
Department of Diabetes and Endocrinology, Singleton Hospital, Swansea Bay University Health Board, Swansea, SA2 8QA, UK
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.
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