Other names：Thymosin Beta 4, tb 500, tb500, tb-500, TMSB4X, Fx Peptide,Timbetasin, PTMB4, Tβ4, TB4X, TMSB4, X-linked, thymosin beta 4 X-linked
Polypeptide TB500, called Thymosin Beta-4 that is a recent discovered bioactive peptide, present in about all human and mammalian cells. This specifically be designed to promote various healing effects in the body(include injury recovery, flexibility, and inflammation etc), and gained significant attention in the medical and scientific communities. Nowadays, TB500 is sold online market as anti-aging and fitness aid, many fitness enthusiasts buy finished TB500 as recovery supplement product alongside a hormone therapy program to increase muscle mass.
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TB500; Thymosin beta4; Thymosin β4; Thymosin b4; Thymosin beta4 Acetate; Thymosin beta(4); Thymosin Beta 4; Thymosin beta-4; Thymosin beta4 (ox); Thymosin beta4 (human); Timbetasin; Tbeta4;
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TB-500 Peptide dosage calculator
Zhao X, Li N.”Thymosin β4 Alleviates Autoimmune Dacryoadenitis via Suppressing Th17 Cell Response”. Invest Ophthalmol Vis Sci. 2023 Aug 1;PMID: 37531112.
Wang X, Zhou Y.”Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation”. 2023 Aug;Epub 2023 May 14.PMID: 37192732.
Effects of thymosin beta 4-derived peptides on migration and invasion of ovarian cancer cells. | Yoon, HJ., et al. 2021. Genes Genomics. 43: 987-993. PMID: 34170491.
Effects of Thymosin beta 4 on Myocardial Apoptosis in Burned Rats. | Wu, X., et al. 2022. J Healthc Eng. 2022: 2129629. PMID: 35281544.
Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans SM, Chen J (Feb 2012). “Thymosin beta 4 is dispensable for murine cardiac development and function”. Circ Res. 110 (3): 456–64.PMC 3739283. PMID 22158707.Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD (Nov 2012). “Doping control analysis of TB-500, a synthetic version of an active region of thymosin β4, in equine urine and plasma by liquid chromatography-mass spectrometry”. Journal of Chromatography A. 1265: 57–69. PMID 23084823.
Van Troys M, Dewitte D, Goethals M, Carlier MF, Vandekerckhove J, Ampe C (Jan 1996). “The actin binding site of thymosin beta 4 mapped by mutational analysis”. The EMBO Journal. 15 (2): 201–10. PMC 449934. PMID 8617195.
Kleinman HK, Sosne G (2016). “Thymosin β4 Promotes Dermal Healing”. Thymosins. review. Vitamins and Hormones. Vol. 102. pp. 251–75. PMID 27450738.
Safer D, Elzinga M, Nachmias VT (March 1991). “Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable”. J. Biol. Chem. 266 (7): 4029–32.PMID 1999398.
Crockford D, Turjman N, Angel J (April 2010). “Thymosin beta4: structure, function, and biological properties supporting current and future clinical applications”. Annals of the New York Academy of Sciences. 1194 (1): 179–89. Bibcode:2010NYASA1194..179C. PMID 20536467. S2CID 29360082.
Sosne G, Kleinman HK (August 2015). “Primary Mechanisms of Thymosin β4 Repair Activity in Dry Eye Disorders and Other Tissue Injuries”. Investigative Ophthalmology & Visual Science. 56 (9): 5110–7.PMID 26241398.
Hypoxia-inducible transcription factor (HIF)-1 alpha stabilization by actin-sequestering protein, thymosin beta-4 (TB4) in Hela cervical tumor cells. Oh JM, Ryoo IJ, Yang Y, Kim HS, Yang KH, Moon EY. Cancer Lett. 264, 29-35, (2008). PMID: 18272284.
Xing Yuan, Ye Yumeng, Zuo Hongyan, Li Yang. Progress on the Function and Application of Thymosin β4. Frontiers in Endocrinology. VOLUME 12 2021.
Kleinman HK, Sosne G (2016). Thymosin β4 Promotes Dermal Healing. review. Vitamins and Hormones. 102. pp. 251–75.
Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012 Jan;12(1):37-51. Epub 2011 Nov 10. PMID: 22074294.
Goldstein AL, Kleinman HK. Advances in the basic and clinical applications of thymosin β4. Expert Opin Biol Ther. 2015;15 Suppl 1:S139-45. Epub 2015 Jun 22. PMID: 26096726.
Maar K, Hetenyi R, Maar S, Faskerti G, Hanna D, Lippai B, Takatsy A, Bock-Marquette I. Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State-New Directions in Anti-Aging Regenerative Therapies. Cells. 2021 May 28; PMCID: PMC8228050.
Author of this article:
Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.
Scientific Journal paper Author:
Racing Laboratory, The Hong Kong Jockey Club, Sha Tin Racecourse, Sha Tin, N.T., Hong Kong, China.
Department of Biochemistry and Medical Chemistry, University of Pecs, Medical School, Pecs H-7624, Hungary.
Department of Ophthalmology, Visual & Anatomical Sciences, Kresge Eye Institute, Wayne State University School of Medicine, 4717 St. Antoine, Detroit, MI 48201, USA.
School of Life Sciences, Division of Physiology, Pharmacology & Neuroscience, University of Nottingham Medical School, Queens Medical Centre, Nottingham NG7 2UH, United Kingdom.
Bozok University School of Medicine, Department of Pathology, Adnan Menderes Bulvarı, No: 44, 66200, Yozgat, Turkey.
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.