Tirzepatide

Authoritative source：PubChem

History of Tirzepatide

In early 2016, Eli Lilly and Company applied for a patent for a method of glycemic control using tirzepatide, with the patent being published later that year.

After successfully passing phase III clinical trials, Lilly applied for FDA approval in October 2021, including a priority review voucher.

In April 2022, following the completion of the SURPASS-2 trial (NCT03987919), Eli Lilly and Company announced that tirzepatide had met their endpoints in obese and overweight patients without diabetes.[1][2]

Industry-funded preliminary trials comparing tirzepatide to the existing diabetes medication semaglutide showed that tirzepatide exhibited slight improvements in reductions in glycated hemoglobin tests (ranging from 2.01% to 2.30% depending on dosage) compared to semaglutide (1.86%). A 10 mg dose of tirzepatide also demonstrated effectiveness in reducing insulin resistance by around 8% from baseline, as measured using HOMA2-IR (computed with fasting insulin). Tirzepatide treatment was found to increase insulin sensitivity by raising fasting levels of IGF binding proteins like IGFBP1 and IGFBP2.

In May 2022, the FDA approved tirzepatide for medical use, specifically as an adjunct to diet and exercise for improving glycemic control in adults with type 2 diabetes mellitus. This approval marked a significant milestone in tirzepatide’s journey from development to clinical use.

Additional, Tirzepatide’s potential for weight loss has led to discussions about its off-label use for obesity treatment, highlighting its multifaceted impact on metabolic health. Individuals considering its use should consult with their doctor to determine if it is a suitable option based on their specific health needs and circumstances. And it is also important to buy Tirzepatide powder from a regular peptide manufacturer.[3][4]

What is Tirzepatide?

Tirzepatide is a novel, once-weekly injectable medication being developed by Eli Lilly and Company for the treatment of type 2 diabetes. It is marketed under the brand name Mounjaro,received FDA approval on May 13, 2022. Tirzepatide acts as a dual agonist for GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors. GIP stimulates insulin release and inhibits glucagon, while GLP-1 enhances insulin secretion, suppresses glucagon, and promotes fullness. Tirzepatide’s combined action optimizes blood sugar control, as insulin uptake increases and glucose production decreases. The synergy of GIP and GLP-1 mechanisms may lead to improved glycemic management and weight loss. Tirzepatide’s innovative approach harnesses the benefits of both hormones, making it a promising therapeutic option for individuals with type 2 diabetes and obesity, addressing multiple aspects of metabolic regulation. According to SURMOUNT-2 study, tirzepatide achieved up to 15.7% weight loss in adults with obesity or overweight and type 2 diabetes.

Tirzepatide powder synthesis

Tirzepatide is an analog of the human GIP hormone with a C20 fatty-diacid portion attached, used to optimise the uptake and metabolism of the compound. The synthesis of tirzepatide powder was first produced by Eli Lilly and Company by standard solid phase peptide synthesis method. Eli Lilly and Company unveiled the synthesis of tirzepatide through patent filings,so now Large-scale manufacturing processes have been reported for this compound. Lead to more and more qualified manufacturers to produce Tirzepatide powder.

Tirzepatide is synthetic peptide. It is administered as a subcutaneous injection and is available in Polypeptide.ltd in raw powder form and lyophilized powder form.[7][8]

Tirzepatide raw powder form

Tirzepatide powder refers to the active ingredient powdered form of the marketed drug Mounjaro. Tirzepatide raw powder is the raw material to produce lyophilized powder Tirzepatide in vials. It is not ready for individuals to use. Only for research.

Reconstitution(Tirzepatide finished vials)

Tirzepatide lyophilized powder form is ready for reconstitution. This lyophilized powder is typically provided in vials or vial kits. The lyophilized powder is then mixed with a suitable diluent, such as bacteriostatic water or sterile water, to create a solution for injection. Reconstitution instructions may vary depending on the specific product and Tirzepatide peptide manufacturer,so it is important to carefully follow the provided guidelines.

How does Tirzepatide works?

Tirzepatide works by acting as a dual agonist for two important hormone receptors: GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1). These hormones are naturally produced in the body and play key roles in regulating blood sugar levels and metabolism.

Stimulation of Insulin Release: Tirzepatide activates the GIP receptor and the GLP-1 receptor, both of which are located on pancreatic beta cells. Activation of these receptors stimulates the release of insulin from the pancreas in response to elevated blood sugar levels. Insulin helps cells take up glucose from the bloodstream, reducing blood sugar levels.[9][10]

Inhibition of Glucagon Release: Tirzepatide also inhibits the release of glucagon, another hormone produced by the pancreas. Glucagon raises blood sugar levels by promoting the release of stored glucose from the liver. By reducing glucagon release, tirzepatide helps prevent excessive glucose production.

Appetite Regulation and Gastric Emptying: GLP-1 receptors are also found in areas of the brain involved in appetite regulation. Activation of these receptors by tirzepatide can help reduce food intake and promote a feeling of fullness. Additionally, GLP-1 slows down gastric emptying, which can help control the rate at which nutrients, including glucose, are absorbed into the bloodstream after eating.

Weight Loss: Tirzepatide’s dual agonist action on both GIP and GLP-1 receptors has been associated with significant weight loss. It may work by modulating fat utilization and promoting a sense of fullness, leading to reduced calorie intake and increased energy expenditure.

By activating GIP and GLP-1 receptors, tirzepatide addresses multiple aspects of blood sugar regulation, insulin release, glucagon inhibition, and appetite control.

Tirzepatide peptide benefits | What Tirzepatide peptide uses for?

Peptide Tirzepatide is primarily used for the management of two key health conditions: type 2 diabetes mellitus and obesity. It offers benefits in both of these areas due to its unique mechanism of action as a dual agonist of GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) receptors. Here are its main uses:

Tirzepatide for Type 2 Diabetes Management

Tirzepatide is FDA-approved as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It helps lower blood sugar levels by enhancing insulin secretion and sensitivity, thereby supporting better glucose regulation.[11][12]

Tirzepatide for Weight Loss

Tirzepatide has shown significant potential for weight reduction. Clinical trials have demonstrated substantial weight loss in individuals who are obese or overweight, making it a potential option for those seeking effective weight management.

Tirzepatide for Cardioprotection (Under Investigation)

Ongoing research is exploring the potential cardioprotective effects of Tirzepatide. Studies are investigating whether its influence on lipoprotein profiles and other factors may contribute to reducing the risk of cardiovascular diseases in individuals with type 2 diabetes.

Other Potential Applications (Under Investigation)

Research is also underway to explore the broader impact of Tirzepatide in conditions beyond diabetes and obesity. This includes its potential role in heart failure with preserved ejection fraction (HFpEF), obstructive sleep apnea (OSA), non-alcoholic steatohepatitis (NASH), chronic kidney disease (CKD), and obesity-related morbidity and mortality. Scientists who want to buy Tirzepatide powder to do the research, make sure buy it from a reliable peptide manufacturer such as Polypeptide.Ltd.[13][14]

Tirzepatide offers a range of notable benefits. Tirzepatide’s unique combination of addressing both diabetes and obesity, along with its potential cardiovascular benefits, positions it as a promising therapeutic option for individuals seeking comprehensive health management.

Tirzepatide dosage – How to use Tirzepatide petide?

Polypeptide.ltd as a Tirzepatide supplier. We only good at producing high quality Tirzepatide powder. The Tirzepatide powder dosage and administration information provided here is for informational purposes only and should not be considered as medical advice. The dosing of tirzepatide can vary based on its intended use for type 2 diabetes and weight loss. Based on multiple studies, here is a general tirzepatide dosage guide:

Tirzepatide dosage for Type 2 Diabetes

Tirzepatide(Mounjaro) is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. The dosing typically follows this pattern:

Initial Dose: 2.5 mg subcutaneous injection once a week for 4 weeks.

Maintenance Dose: Increase to 5 mg subcutaneous injection once a week after the initial 4 weeks.

Titration: If additional glycemic control is needed, the dose can be increased in 2.5 mg increments after at least 4 weeks at the current dose.

Maximum Dose: The maximum recommended dose is 15 mg subcutaneous injection once a week.

Please note that the initial 2.5 mg dose is for treatment initiation and is not effective for glycemic control. You will need to adjust your dosage based on your response and needs.[15]

Tirzepatide dosage for Weight Loss

Tirzepatide has been shown to help lose weight in overweight patients. The dosing for weight loss may be different and can be informed by clinical trials such as SURMOUNT-1 and SURMOUNT-2. Polypeptide.ltd as Tizepatide powder manufacturer don’t teach how to use Tirzepatide. But a potential weight loss protocol could be:

Initial Dose: 2.5 mg subcutaneous injection once a week for the first four weeks.

Progressive Increase: Increase the dose to 5 mg weekly in weeks 5-8, 7.5 mg weekly in weeks 9-12, and 10 mg weekly in weeks 13-16.

Further Adjustment: Depending on individual response and tolerance, consider increasing to 12.5 mg weekly in weeks 17-20, and up to a maximum dose of 15 mg weekly from week 21 onwards.

Frequency and Duration: Administer once-weekly subcutaneous injections, and studies using this protocol have lasted 24-72 weeks.

It’s essential to consult your healthcare provider before making any changes to your medication dosage. This guide is a general overview and should not replace personalized medical advice. Your healthcare provider will determine the most appropriate dosing regimen for your specific condition and needs.

Tirzepatide vs semaglutide, which one is better on weight loss?

Tirzepatide peptide and Semaglutide (Ozempic) are both in the class of drugs known as incretin mimetics but have some differences. Tirzepatide powder acts on both GIP and GLP-1 receptors, while Semaglutide acts only on GLP-1 receptors; however, both drugs are effective treatments for type 2 diabetes.

In direct comparison, Tirzepatide appears to have a broader range of activity due to its dual-action mechanism involving both GIP and GLP-1 receptors. Clinical trials have indicated that Tirzepatide powder may lead to greater weight loss compared to semaglutide, presenting it as a potentially more effective option for individuals seeking significant weight reduction.

It’s important to note that individual responses to medications can vary, and the choice between tirzepatide and semaglutide should be based on a thorough assessment of each patient’s medical history, treatment goals, and preferences. Healthcare providers can help determine the most suitable option for each individual.

Tirzepatide side effects and safety

Tirzepatide is a prescription medication that has been approved by regulatory authorities, such as the U.S. Food and Drug Administration (FDA) in the United States, the European Medicines Agency (EMA) in the European Union, Health Canada in Canada, and other relevant health authorities in various countries. These approvals indicate that Tirzepatide has undergone rigorous testing and evaluation to establish its safety, efficacy, and quality standards for the treatment of specific medical conditions, such as type 2 diabetes and obesity.

Tirzepatide has undergone extensive clinical trials to assess its safety profile. Overall, it has been found to be generally safe and well-tolerated by patients when used as prescribed. As biological drugs, Tirzepatide peptide have relatively small side effects than traditional chemical weight loss products. Here some of Tirzepatide side effects reported:

Common side effects of tirzepatide may include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and abdominal pain. These side effects are often mild and tend to improve over time as the body adjusts to the medication.

In clinical trials, some participants taking tirzepatide experienced injection site reactions, such as redness or irritation at the injection site. There is also a possibility of hypoglycemia (low blood sugar) when tirzepatide is used in combination with other antidiabetic medications that can lower blood sugar levels.

Tirzepatide powder mixing instructions

Tirzepatide is most commonly available for research purposes as a lyophilized powder, which is a freeze-dried version of the peptide. Before administering it, researchers and scientists must reconstitute the lyophilized powder with an appropriate solvent, such as bacteriostatic water or sterile saline solution. Follow these simple steps to reconstitute Tirzepatide powder for use:

Step 1: Gather Supplies

Make sure you have the following:

Tirzepatide powder

Sterile water for injection

Vial adapter

Syringe

Step 2: Prepare Work Area

Choose a clean, well-lit space free from contaminants.

Step 3: Wash Hands

Thoroughly wash your hands with soap and water to prevent contamination.

Step 4: Reconstitute the Tirzepatide Powder

Follow these steps:

Remove vial cap.

Clean rubber stopper with an alcohol swab.

Attach vial adapter to the vial.

Insert syringe into vial adapter.

Slowly inject sterile water into vial.

Gently swirl vial to mix (no vigorous shaking).

Ensure full dissolution.

Step 5: Withdraw Mixed Solution

After full dissolution:

Hold vial upside down, insert syringe into adapter.

Slowly pull back plunger to withdraw desired dose.

Check for air bubbles, tap syringe gently to remove.

Step 6: Administer Medication

Follow healthcare provider’s instructions for injection technique and site.

Remember, proper mixing ensures the effectiveness of Tirzepatide for your treatment. Always consult your healthcare provider for guidance.

How to store Tirzepetide peptide?

Lyophilized powder form Tirzepatide should be stored in the refrigerator (between 2-8ºC). Keep tirzepatide in original package until use to protect from light. Single-dose pens (Tirzepatide injection liquid) can be stored at room temperature for 21 days, if needed. Do Not freeze Tirzepatide. Freezing can potentially damage the medication and affect its effectiveness. Store your medication only as directed by your Tirzepatide supplier such as Polypeptide.Ltd. Make sure you understand how to store your peptide properly.

Tirzepatide for sale | Where to buy Tirzepatide peptide

Tirzepatide presents a potential breakthrough for managing obesity and type 2 diabetes. By targeting GIP and GLP-1 receptors, it promotes weight loss and improves glycemic control simultaneously. With promising clinical results, more and more overweight patient want to buy Tirzepatide, but the current prescribed Tirzepatide price stop most of them because the drug is only covered for patients with type 2 diabetes, utilization for weight loss is considered off-label and not covered by a patient’s insurance.

However, as technology continues to mature, more and more peptide manufacturer such as Polypeptide. Ltd and research companies can synthesize Tirzepatide powder by their independent lab. Tirzepatide powder is primarily available in the form of synthetic peptide. There are many Tirzepatide for sale online now, finding a reliable source to buy Tirzepatide powder can be a challenging task. Researchers who are interested in experimenting with Tirzepatide powder will want to ensure that they source this material from a reliable supplier.[5][6] lf you’re looking to buying  Tirzepatide powder online, Polypetide.Ltd will be the one of Tirzepatide manufacturers you don’t want to miss. And buy Tirzepatide powder bulk will get a good price.